chlordiazepoxide (Librium)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: chlordiazepoxide hydrochloride

BRAND NAME: Librium

DRUG CLASS AND MECHANISM: Chlordiazepoxide is a psychotropic agent that is used to manage symptoms associated with anxiety disorders. It is a long acting benzodiazepine that is available for oral administration. Examples of other members of the benzodiazepine include:

Chlordiazepoxide has anti-anxiety, sedative, appetite-stimulating, and weak pain relieving properties. The exact mechanism of how chlordiazepoxide provides therapeutic benefits is not yet understood. However, current understanding of benzodiazepines indicates that they enhance or increase the activity of GABA, an inhibitory neurotransmitter, a chemical that cells in the brain use to suppress the activity of other cells.

Chlordiazepoxide was initially approved by the US FDA in 1960. The injectable formulation of chlordiazepoxide is no longer available in the US.

PRESCRIBED FOR: Chlordiazepoxide is used for the management of anxiety disorders. It is used to provide short term relief of anxiety symptoms, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. Effectiveness and safety of long term use of chlordiazepoxide has not been determined.

SIDE EFFECTS: Reported side effects include:

Medically Reviewed by a Doctor on 12/22/2014
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