GENERIC NAME: chlordiazepoxide hydrochloride
BRAND NAME: Librium
DRUG CLASS AND MECHANISM: Chlordiazepoxide is a psychotropic agent that is used to manage symptoms associated with anxiety disorders. It is a long acting benzodiazepine that is available for oral administration. Examples of other members of the benzodiazepine include:
Chlordiazepoxide has anti-anxiety, sedative, appetite-stimulating, and weak pain relieving properties. The exact mechanism of how chlordiazepoxide provides therapeutic benefits is not yet understood. However, current understanding of benzodiazepines indicates that they enhance or increase the activity of GABA, an inhibitory neurotransmitter, a chemical that cells in the brain use to suppress the activity of other cells.
Chlordiazepoxide was initially approved by the US FDA in 1960. The injectable formulation of chlordiazepoxide is no longer available in the US.
PRESCRIBED FOR: Chlordiazepoxide is used for the management of anxiety disorders. It is used to provide short term relief of anxiety symptoms, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. Effectiveness and safety of long term use of chlordiazepoxide has not been determined.
SIDE EFFECTS: Reported side effects include:
- Impaired muscle control (ataxia)
- Skin problems
- Minor menstrual irregularities
- Movement disorders
- Decreased desire for sexual activity (decreased libido).
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