cerivastatin, Baycol (cont.)
GENERIC AVAILABLE: no
PREPARATIONS: Tablets, 0.3mg, 0.4mg, and 0.8mg.
STORAGE: Tablets should be stored at room temperature, 15-30°C (59-86°F).
PRESCRIBED FOR: Cerivastatin is used for the treatment of high blood cholesterol. Elevated blood cholesterol first is treated with exercise, weight loss, and a diet low in cholesterol and saturated fats. If these measures fail to reduce the cholesterol adequately, cholesterol-lowering medications such as cerivastatin may be added. The National Cholesterol Education Program (NCEP) has published treatment guidelines for using drugs such as cerivastatin. These guidelines recommend treatment depending on the level of LDL cholesterol as well as the presence of other risk factors such as diabetes, hypertension, cigarette smoking, low HDL cholesterol level (the "good" cholesterol), and family history of early coronary heart disease. The effectiveness of cerivastatin in lowering cholesterol is dose-related, that is, the higher the dose the greater the lowering of cholesterol. Blood cholesterol determinations are performed at regular intervals during treatment so that the dose may be adjusted.
DOSING: Cerivastatin usually is taken once daily at bedtime. It may be taken with or without food.
DRUG INTERACTIONS: With other drugs in the same class as cerivastatin, the risk of muscle damage (see below) is increased when they are given at the same time as other medications such as cyclosporine (Sandimmune; Neoral), gemfibrozil (Lopid), erythromycin, itraconazole (Sporanox) and nicotinic acid. It is assumed that cerivastatin will interact similarly.
PREGNANCY: It is not known if cerivastatin causes harm to the fetus if taken during pregnancy. Cerivastatin may be used in pregnancy if the physician feels that its benefits outweigh its potential risks.
NURSING MOTHERS: It is not known if cerivastatin is secreted in breast milk. Therefore, the physician and patient must weigh the benefits against the potential risks of treating nursing mothers.
SIDE EFFECTS: Cerivastatin generally is well-tolerated, and side effects are rare. Minor side effects include constipation, diarrhea, fatigue, gas, heartburn, nasal congestion, and headache. Cerivastatin should be used with caution in patients with alcoholic or other liver diseases. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication. Rare cases of muscle damage due to inflammation (myositis) have been reported with other drugs in the same class as cerivastatin, and is presumed also to occur with cerivastatin as well. (Muscle inflammation causes the release of muscle protein, myoglobin, into the blood where it is carried to the kidneys and leads to kidney failure.)
Reference: FDA Prescribing Information
Last Editorial Review: 1/16/2000
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