celecoxib (cont.)
NURSING MOTHERS: Available evidence suggests that celecoxib is
secreted in breast milk. Nursing mothers should avoid celecoxib or discontinue
breastfeeding.
SIDE EFFECTS: The most common adverse effects are headache,
abdominal
pain, dyspepsia, diarrhea, nausea,
flatulence, and insomnia. Other side effects
include fainting, kidney failure, heart failure, aggravation of
hypertension,
chest pain,
ringing in the ears, deafness, stomach and intestinal ulcers,
bleeding, blurred vision, anxiety,
photosensitivity, weight gain, water
retention, flu-like symptoms, drowsiness and weakness.
Celecoxib, like other
NSAIDs may cause serious stomach and intestinal ulcers that may occur at any
time during treatment. Celecoxib does not interfere with the function of the
blood platelets and, as a result, does not reduce clotting and lead to increased
bleeding time like other NSAIDs. Allergic reactions can occur with celecoxib.
Individuals who have developed allergic reactions (rash, itching, difficulty
breathing) from sulfonamides [for example,
sulfamethoxazole and trimethoprim (Bactrim)], aspirin or other NSAIDs may
experience an allergic reaction to celecoxib and should not take celecoxib.
NSAIDs may increase the risk of heart attacks, stroke, and related
conditions, which can be fatal. This risk may increase with duration of use and
in patients who have underlying risk factors for heart and blood vessel
conditions. NSAIDs should not be used for the treatment of pain resulting from
coronary artery bypass graft (CABG) surgery. NSAIDs cause an increased risk of
serious, even fatal, stomach and intestinal adverse reactions such as bleeding,
ulcers, and perforation of the stomach or intestines. These events can occur at
any time during treatment and without warning symptoms. Elderly patients are at
greater risk for these types of reactions.
Reference: FDA Prescribing Information
Last Editorial Review: 12/15/2008
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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