cefuroxime, Ceftin, Zinacef (cont.)

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DOSING: Typical adult oral doses are 250 or 500 mg twice daily for 7-20 days depending on the type and severity of the infection. A single 1000 mg dose may used for uncomplicated gonorrhea. The tablets and suspension are not interchangeable.

DRUG INTERACTIONS: Probenecid increases the concentration of cefuroxime in the blood. Drugs that reduce acidity in the stomach (for example, antacids, H2-blockers, proton pump inhibitors) may reduce absorption of cefuroxime.

PREGNANCY: Cephalosporins are usually considered safe for use during pregnancy.

NURSING MOTHERS: Cefuroxime is excreted in breast milk and may cause adverse effects in the infant. Cefuroxime is approved for pediatric patients 3 months and older.

SIDE EFFECTS: Cefuroxime is generally well tolerated, and side effects are usually transient. Side effects include diarrhea, nausea, vomiting, abdominal pain, headache, rash, hives, vaginitis, and mouth ulcers. Allergic reactions, severe skin reactions, anemia, and seizures also may occur. Since cefuroxime is chemically related to penicillin, patients allergic to penicillin may develop an allergic reaction (sometimes even anaphylaxis) to cefuroxime. Cefuroxime like other antibiotics can alter the colon's normal bacteria, leading to overgrowth of a bacterium called Clostridium difficile. Overgrowth of this bacterium leads to the release of toxins that contribute to the development of Clostridium difficile-associated diarrhea, which may range in severity from mild diarrhea to fatal pseudomembranous colitis.

Reference: FDA Prescribing Information


Last Editorial Review: 2/14/2012



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