cefpodoxime proxetil, (Vantin, Banan [discontinued]) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
PREPARATIONS: Tablet: 100 and 200 mg; Granules for Oral Suspension: 50 and 100 mg/5 ml
DRUG INTERACTIONS: Probenecid increases the concentration of cefpodoxime in the blood. Drugs that reduce acidity in the stomach (for example, antacids, H2-blockers, proton pump inhibitors) may reduce absorption of cefpodoxime.
Combining cefpodoxime with drugs that reduce kidney function may increase the risk of harm to the kidney.
STORAGE: Tablets and granules should be stored at room temperature, 20 C – 25 C (68 F – 77 F). After mixing the granules with water, the suspension should be stored in a refrigerator, 2 C to 8 C (36 F to 46 F). The suspension should be shaken well before using and discarded ifunused after 14 days.
PREGNANCY AND BREASTFEEDING SAFETY:Safety in pregnancy has not been established for cefpodoxime. There are no adequate studies in pregnant women; however, studies in animals suggest no important effects on the fetus.
Cefpodoxime is excreted in human milk. The levels of cefpodoxime in human milk were 0, 2 and 6% of blood levels at 4 hours after a 200 mg oral dose. At 6 hours after dosing, the levels in breast milk were 0, 9 and 16% of the concentration of cefpodoxime in blood. Women should decide whether to discontinue nursing or to discontinue the drug.
DRUG CLASS AND MECHANISM:
Medically reviewed by Omudhome Ogbru, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 1/19/2016
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