PREPARATIONS: Tablets: 400 mg. Tablet (Chewable): 100, 200 mg. Suspension: 100,200, 500 mg/5 ml.
DRUG INTERACTIONS: Probenecid (Benemid) may increase the blood concentration of cefixime by decreasing removal of cefixime by the kidney. This interaction sometimes is used to enhance the effect of cephalosporins.
Combining cefixime with aminoglycosides (for example, tobramycin [Tobradex] produces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney.)
Cefixime may cause a false positive urine ketone test.
PREGNANCY AND BREASTFEEDING SAFETY: Safety in pregnancy has not been established for cefixime. There are no adequate studies in pregnant women; however, studies in animals suggest no important effects on the fetus.
Safety in nursing mothers has not been established. It is not known if cefixime is excreted in breast milk.
STORAGE: Tablets and oral suspension may be stored at room temperature, 20 C to 25 C (68 F to 77 F), in a tightly closed container. Suspension may be refrigerated or stored at room temperature after mixing.
DOSING: The recommended adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours. Pediatric patients (6 months and older) have a recommended dose of 8 mg/kg/day once daily or in two doses of 4/mg/kg every 12 hours.
DRUG CLASS AND MECHANISM: Cefixime is a semi-synthetic (partially man-made), oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and many injectable forms. Like other cephalosporins, cefixime stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together; most bacteria cannot survive without a cell wall. Cefixime is active against a very wide spectrum of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (the cause of strep throat), Hemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae. The FDA approved cefixime in April 1989.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing Information
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