cefixime (Suprax) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 400 mg. Tablet (Chewable): 100, 200 mg. Suspension: 100,200, 500 mg/5 ml.

STORAGE: Tablets and oral suspension may be stored at room temperature, 20 C to 25 C (68 F to 77 F), in a tightly closed container. Suspension may be refrigerated or stored at room temperature after mixing.

PRESCRIBED FOR: Cefixime is effective for infections of the middle ear (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, and pneumonia caused by susceptible bacteria. It also is used for treating urinary tract infections and gonorrhea as well as acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD).

DOSING: The recommended adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours. Pediatric patients (6 months and older) have a recommended dose of 8 mg/kg/day once daily or in two doses of 4/mg/kg every 12 hours.

DRUG INTERACTIONS: Probenecid (Benemid) may increase the blood concentration of cefixime by decreasing removal of cefixime by the kidney. This interaction sometimes is used to enhance the effect of cephalosporins.

Combining cefixime with aminoglycosides (for example, tobramycin [Tobradex] produces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney.)

Exenatide (Byetta) may delay or reduce the absorption of cephalosporins. Cephalosporins should be administered one hour before exenatide.

Cefixime may cause a false positive urine ketone test.

PREGNANCY: Safety in pregnancy has not been established for cefixime. There are no adequate studies in pregnant women; however, studies in animals suggest no important effects on the fetus.

Medically Reviewed by a Doctor on 10/10/2014


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