carvedilol (Coreg, Coreg CR) (cont.)

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  • Tablets: 3.125, 6.25, 12.5, and 25 mg.
  • Capsules (Extended Release): 10, 20, 40, 80 mg

STORAGE: Tablets should be stored at room temperature, 15 C and 30 C (59 F and 86 F).

DOSING: Carvedilol tablets are usually given twice daily. For high blood pressure, the dose is 6.25 mg twice daily to a maximum of 25 mg twice daily.

For congestive heart failure, the dose is 3.25 mg twice daily to a maximum of 25 mg twice daily. A maximum dose of 50 mg twice daily has been used in persons weighing more than 85 kg (187 pounds).

Carvedilol should be taken with food to slow its absorption and reduce the occurrence of low blood pressure when rising from a sitting or sleeping position (orthostatic hypotension). Stopping and changing doses of carvedilol should be done under the direction of a physician since sudden changes in dose can result in serious cardiac complications such as arrhythmias.

The dose range for treating heart failure or high blood pressure with extended release capsules is 10 to 80 mg once daily.

DRUG INTERACTIONS: Carvedilol can mask early warning symptoms of low blood sugar (hypoglycemia) such as tremors and increased heart rate. (These symptoms are caused by activation of the adrenergic nervous system which is blocked by the carvedilol.) Therefore, patients with diabetes taking medications that lower blood sugar such as insulin or oral anti-diabetic medications may need to monitor their blood sugar more often.

Carvedilol taken with calcium channel blockers (CCBs) such as diltiazem (Cardizem) or verapamil (Calan) may trigger an irregular heart rhythm or an increase in blood pressure.

Medically Reviewed by a Doctor on 9/18/2015

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