Carcinoid Syndrome (Carcinoid Tumor)

  • Medical Author:
    Dennis Lee, MD

    Dr. Lee was born in Shanghai, China, and received his college and medical training in the United States. He is fluent in English and three Chinese dialects. He graduated with chemistry departmental honors from Harvey Mudd College. He was appointed president of AOA society at UCLA School of Medicine. He underwent internal medicine residency and gastroenterology fellowship training at Cedars Sinai Medical Center.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical Editor: Bhupinder S. Anand, MBBS, MD, DPHIL (OXON)
    Bhupinder S. Anand, MBBS, MD, DPHIL (OXON)

    Bhupinder S. Anand, MBBS, MD, DPHIL (OXON)

    Dr. Anand received MBBS degree from Medical College Amritsar, University of Punjab. He completed his Internal Medicine residency at the Postgraduate Institute of medical Education and Research, Chandigarh, India. He was trained in the field of Gastroenterology and obtained the DPhil degree. Dr. Anand is board-certified in Internal Medicine and Gastroenterology.

woman with abdominal pain

Causes of Flushing or Hot Flashes

Hot flashes or flushing are considered to be a characteristic symptom of the menopausal transition; however, they also can occur in men due to conditions such as low testosterone. Flushing also can occur in people as a result of certain rare medical conditions such as carcinoid syndrome, a medical condition in which a carcinoid tumor secretes large amounts of serotonin, a hormone produced by the body.

Additional symptoms of carcinoid syndrome or carcinoid tumor include:

  • Abdominal pain
  • Wheezing
  • Niacin deficiency
  • Diarrhea (up to 20 times per day)
  • Gastrointestinal bleeding

Carcinoid tumor definition and facts

  • Carcinoid tumors are rare tumors that develop from hormone-producing cells called enterochromaffin cells that occur throughout the body, with approximately 65% originating in the gastrointestinal tract and 25% in the lungs.
  • Carcinoid tumors can occur almost anywhere in the gastrointestinal tract but primarily in the stomach, small intestine, appendix, colon, and rectum.
  • Carcinoid tumors can be benign (non-cancerous) or malignant (cancerous). Even when they are malignant, carcinoid tumors usually are slow to grow and to spread.
  • The carcinoid syndrome is a syndrome that is caused by the release of hormones and other chemical substances called vasoactive amines from the carcinoid tumor.
  • The carcinoid syndrome may include signs and symptoms such as
  • Carcinoid tumors can be found by endoscopy, barium small intestinal X-ray studies, and by capsule enteroscopy. Their diagnosis requires a biopsy to provide a tissue sample.
  • Metastatic carcinoid tumors can be diagnosed by CT or MRI scans, indium 111 octreotide scans, and bone scans.
  • Carcinoid tumors can be managed and treated with observation, surgery, cryotherapy, radiofrequency ablation, hepatic artery embolization, interferon therapy, chemotherapy, and radiation therapy.
  • The carcinoid syndrome's signs or symptoms can be blocked or lessened by medication.
  • The prognosis and survival rate for someone with carcinoid tumor varies with the extent of the metastatic disease in the presence of the carcinoid syndrome. The clinical course of these cancers is often indolent with 5 year survival approaching 75%. Current treatment is not curative, but patients can be helped by palliative measures.
Medically Reviewed by a Doctor on 8/22/2016

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