Carcinoembryonic Antigen
(CEA)
What is CEA?
CEA stands for carcinoembryonic antigen. CEA is a type of protein molecule that can be found in many different cells
of the body, but is typically associated with certain tumors and the developing fetus. The word "carcinoembryonic" reflects the fact
that CEA is produced by some cancers ("carcino-") and by the developing fetus
("-embryonic").
How is CEA measured?
CEA is most frequently tested in blood. It can also be tested in body fluids and in biopsy tissue.
What is the normal range for CEA blood levels?
The normal range for CEA in an adult non-smoker is <2.5 ng/ml and for a smoker <5.0 ng/ml.
How is the CEA test used?
The best use of CEA is as a tumor marker, especially for cancers of the gastrointestinal tract. When the CEA level is abnormally
high before surgery or other treatment, it is expected to fall to normal following successful surgery to remove all of the cancer. A rising CEA
level indicates progression or recurrence of the cancer. In addition, levels >20 ng/ml before therapy are associated with cancer which has
already spread (metastatic disease).
What conditions can cause an elevated CEA?
Both benign and malignant (harmless and cancerous) conditions can increase the CEA level. The most frequent cancer which causes
an increased CEA is cancer of the colon and rectum. Others include cancers of the pancreas, stomach, breast, lung, and certain types of
thyroid and ovarian cancer. Benign conditions which can elevate CEA include smoking, infections, inflammatory bowel disease, pancreatitis,
cirrhosis of the liver, and some benign tumors in the same organs in which an elevated CEA indicates cancer. Chemotherapy and radiation
therapy can cause a temporary rise in CEA due to the death of tumor cells and release of CEA into the blood stream. Benign disease does
not usually cause an increase above 10 ng/ml.
What are the limitations of CEA testing?
CEA is not an effective screening test for hidden (occult) cancer since early tumors do not cause significant blood elevations. Also,
many tumors never cause an abnormal blood level, even in advanced disease. Because there is variability between results obtained between
laboratories, the same laboratory should do repeat testing when monitoring a patient with cancer.
Last Editorial Review: 4/22/2002
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