carboprost tromethamine (Hemabate)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Which drugs or supplements interact with carboprost tromethamine?

Carboprost should not be administered with oxytocin (Pitocin) because both medications work similarly. Oxytocin also induces contractions during labor; therefore, use of both medications is not recommended.

Is carboprost tromethamine safe to use during pregnancy or while breastfeeding?

It should be used only for termination of pregnancy and to treat hemorrhage after delivery.

It is not known whether carboprost is excreted in breast milk.

What else should I know about carboprost tromethamine?

What preparations of carboprost tromethamine are available?

Injectable: 250 mcg/ml

How should I keep carboprost tromethamine stored?

Carboprost injectable should be refrigerated at 2 C to 8 C (36 F to 46 F).

How does carboprost tromethamine work?

Oxytocic medications have the effects of oxytocin, which causes contractions during labor and controls bleeding after childbirth. Carboprost works on prostaglandin F receptor sites in uterine muscle to increase contractions and induce labor. It is used to terminate pregnancies and control uterine bleeding.

When was carboprost tromethamine approved by the FDA?

The FDA approved carboprost tromethamine in January 1979.

Medically reviewed by John P. Cunha, MD

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 2/9/2017
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