carboprost tromethamine (Hemabate) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

It also may cause:

  • Endometritis (inflammation of the lining of the uterus)
  • Retained placental fragments
  • Excessive uterine bleeding

Hypersensitivity with allergic reactions may occur. Therefore, patients must be under medical supervision while carboprost is being administered.



PREPARATIONS: Injectable: 250 mcg/ml

STORAGE: Carboprost injectable should be refrigerated at 2 C to 8 C (36 F to 46 F).


  • Termination of pregnancy, during second trimester: Inject 250 mcg (1 ml) intramuscularly, then administer 250 mcg (1 ml) to 500 mcg (2 ml) every 1.5 to 3.5 hours based on patient response. The total dose should not exceed 12 mg.
  • Postpartum hemorrhage: Inject 250 mcg (1 ml) intramuscularly; repeat every 15 to 90 minutes as needed. The total dose should not exceed 2 mg.

DRUG INTERACTIONS: Carboprost should not be administered with oxytocin (Pitocin) because both medications work similarly. Oxytocin also induces contractions during labor; therefore, use of both medications is not recommended.

PREGNANCY: It should be used only for termination of pregnancy and to treat hemorrhage after delivery.

NURSING MOTHERS: It is not known whether carboprost is excreted in breast milk.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 12/24/2014

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