carboprost tromethamine (Hemabate)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Do I need a prescription for carboprost tromethamine?

Yes

Why is carboprost tromethamine prescribed to patients?

Carboprost is used to abort pregnancy during the second trimester and to treat uterine bleeding after delivery.

What are the side effects of carboprost tromethamine?

Common side effects of carboprost are:

It also may cause:

  • Endometritis (inflammation of the lining of the uterus)
  • Retained placental fragments
  • Excessive uterine bleeding

Hypersensitivity with allergic reactions may occur. Therefore, patients must be under medical supervision while carboprost is being administered.

What is the dosage for carboprost tromethamine?

  • Termination of pregnancy, during second trimester: Inject 250 mcg (1 ml) intramuscularly, then administer 250 mcg (1 ml) to 500 mcg (2 ml) every 1.5 to 3.5 hours based on patient response. The total dose should not exceed 12 mg.
  • Postpartum hemorrhage: Inject 250 mcg (1 ml) intramuscularly; repeat every 15 to 90 minutes as needed. The total dose should not exceed 2 mg.

Which drugs or supplements interact with carboprost tromethamine?

Carboprost should not be administered with oxytocin (Pitocin) because both medications work similarly. Oxytocin also induces contractions during labor; therefore, use of both medications is not recommended.

Is carboprost tromethamine safe to use during pregnancy or while breastfeeding?

It should be used only for termination of pregnancy and to treat hemorrhage after delivery.

It is not known whether carboprost is excreted in breast milk.

What else should I know about carboprost tromethamine?

What preparations of carboprost tromethamine are available?

Injectable: 250 mcg/ml

How should I keep carboprost tromethamine stored?

Carboprost injectable should be refrigerated at 2 C to 8 C (36 F to 46 F).

How does carboprost tromethamine work?

Oxytocic medications have the effects of oxytocin, which causes contractions during labor and controls bleeding after childbirth. Carboprost works on prostaglandin F receptor sites in uterine muscle to increase contractions and induce labor. It is used to terminate pregnancies and control uterine bleeding.

When was carboprost tromethamine approved by the FDA?

The FDA approved carboprost tromethamine in January 1979.

REFERENCE: FDA Prescribing Information.

Last Editorial Review: 2/9/2017

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Reviewed on 2/9/2017
References
REFERENCE: FDA Prescribing Information.

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