GENERIC NAME: carboprost tromethamine
BRAND NAME: Hemabate
DRUG CLASS AND MECHANISM: Carboprost is a man-made oxytocic medication that mimics the action of a naturally occurring chemical called prostaglandin F2 alpha. Oxytocic medications have the effects of oxytocin, which causes contractions during labor and controls bleeding after childbirth. Carboprost works on prostaglandin F receptor sites in uterine muscle to increase contractions and induce labor. It is used to terminate pregnancies and control uterine bleeding.
The FDA approved carboprost tromethamine in January 1979.
PRESCRIBED FOR: Carboprost is used to abort pregnancy during the second trimester and to treat uterine bleeding after delivery.
SIDE EFFECTS: Common side effects of carboprost are:
It also may cause:
- Endometritis (inflammation of the lining of the uterus)
- Retained placental fragments
- Excessive uterine bleeding
Hypersensitivity with allergic reactions may occur. Therefore, patients must be under medical supervision while carboprost is being administered.
GENERIC AVAILABLE: No
PREPARATIONS: Injectable: 250 mcg/ml
STORAGE: Carboprost injectable should be refrigerated at 2 C to 8 C (36 F to 46 F).
- Termination of pregnancy, during second trimester: Inject 250 mcg (1 ml) intramuscularly, then administer 250 mcg (1 ml) to 500 mcg (2 ml) every 1.5 to 3.5 hours based on patient response. The total dose should not exceed 12 mg.
- Postpartum hemorrhage: Inject 250 mcg (1 ml) intramuscularly; repeat every 15 to 90 minutes as needed. The total dose should not exceed 2 mg.
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