carboprost tromethamine (Hemabate)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is carboprost tromethamine?

Carboprost (Hemabate) is a man-made oxytocic medication that mimics the action of a naturally occurring chemical called prostaglandin F2 alpha. It treats bleeding in new mothers immediately after delivery.

Is carboprost tromethamine available as a generic drug?

No

Do I need a prescription for carboprost tromethamine?

Yes

Why is carboprost tromethamine prescribed to patients?

Carboprost is used to abort pregnancy during the second trimester and to treat uterine bleeding after delivery.

What are the side effects of carboprost tromethamine?

Common side effects of carboprost are:

It also may cause:

  • Endometritis (inflammation of the lining of the uterus)
  • Retained placental fragments
  • Excessive uterine bleeding

Hypersensitivity with allergic reactions may occur. Therefore, patients must be under medical supervision while carboprost is being administered.

What is the dosage for carboprost tromethamine?

  • Termination of pregnancy, during second trimester: Inject 250 mcg (1 ml) intramuscularly, then administer 250 mcg (1 ml) to 500 mcg (2 ml) every 1.5 to 3.5 hours based on patient response. The total dose should not exceed 12 mg.
  • Postpartum hemorrhage: Inject 250 mcg (1 ml) intramuscularly; repeat every 15 to 90 minutes as needed. The total dose should not exceed 2 mg.
Medically Reviewed by a Doctor on 2/9/2017
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