carboprost tromethamine (Hemabate)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

19 Habits That Wreck Your Teeth

GENERIC NAME: carboprost tromethamine

BRAND NAME: Hemabate

DRUG CLASS AND MECHANISM: Carboprost is a man-made oxytocic medication that mimics the action of a naturally occurring chemical called prostaglandin F2 alpha. Oxytocic medications have the effects of oxytocin, which causes contractions during labor and controls bleeding after childbirth. Carboprost works on prostaglandin F receptor sites in uterine muscle to increase contractions and induce labor. It is used to terminate pregnancies and control uterine bleeding.

The FDA approved carboprost tromethamine in January 1979.

PRESCRIBED FOR: Carboprost is used to abort pregnancy during the second trimester and to treat uterine bleeding after delivery.

SIDE EFFECTS: Common side effects of carboprost are:

It also may cause:

  • Endometritis (inflammation of the lining of the uterus)
  • Retained placental fragments
  • Excessive uterine bleeding

Hypersensitivity with allergic reactions may occur. Therefore, patients must be under medical supervision while carboprost is being administered.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Injectable: 250 mcg/ml

STORAGE: Carboprost injectable should be refrigerated at 2 C to 8 C (36 F to 46 F).

DOSING:

  • Termination of pregnancy, during second trimester: Inject 250 mcg (1 ml) intramuscularly, then administer 250 mcg (1 ml) to 500 mcg (2 ml) every 1.5 to 3.5 hours based on patient response. The total dose should not exceed 12 mg.
  • Postpartum hemorrhage: Inject 250 mcg (1 ml) intramuscularly; repeat every 15 to 90 minutes as needed. The total dose should not exceed 2 mg.
Medically Reviewed by a Doctor on 12/24/2014
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