captopril and hydrochlorothiazide, Capozide (cont.)

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STORAGE: Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING: The starting dose is 25/15 mg once daily. The dose may be increased every 6 weeks.

DRUG INTERACTIONS: Captopril may increase potassium levels (hyperkalemia) in blood. Therefore, there is an increased risk of hyperkalemia when captopril is given with potassium supplements or drugs that increase potassium levels (for example, spironolactone [Aldactone]).

There have been reports of increased lithium (Eskalith, Lithobid) levels when lithium is used in combination with ACE inhibitors. The reason for this interaction is not known, but the increased levels may lead to toxicity from lithium.

There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors.

Medically Reviewed by a Doctor on 6/17/2015

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