captopril and hydrochlorothiazide, Capozide (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Capozide is used to treat high blood pressure. It may be used as initial treatment or substituted for the individual component drugs.

SIDE EFFECTS: A dry, persistent cough has been reported commonly with the use of ACE inhibitors. Coughing resolves after discontinuing the drug.

Other common side effects include:

Increased blood glucose and potassium levels also may occur.

Serious but, fortunately, very rare side effects are liver failure angioedema (swelling of lips and throat that can obstruct breathing).

Capozide may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis (narrowing of both arteries going to the kidneys).

Rare cases of rhabdomyolysis (muscle breakdown), reduced number of platelets, and pancreatitis have been reported.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets (captopril/HCTZ): 25/15, 25/25, 50/15, and 50/25 mg.

STORAGE: Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING: The starting dose is 25/15 mg once daily. The dose may be increased every 6 weeks.

DRUG INTERACTIONS: Captopril may increase potassium levels (hyperkalemia) in blood. Therefore, there is an increased risk of hyperkalemia when captopril is given with potassium supplements or drugs that increase potassium levels (for example, spironolactone [Aldactone]).

Medically Reviewed by a Doctor on 6/17/2015


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