captopril and hydrochlorothiazide, Capozide (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Capozide is used to treat high blood pressure. It may be used as initial treatment or substituted for the individual component drugs.
SIDE EFFECTS: A dry, persistent cough has been reported commonly with the use of ACE inhibitors. Coughing resolves after discontinuing the drug.
Other common side effects include:
Increased blood glucose and potassium levels also may occur.
Serious but, fortunately, very rare side effects are liver failure angioedema (swelling of lips and throat that can obstruct breathing).
Capozide may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis (narrowing of both arteries going to the kidneys).
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets (captopril/HCTZ): 25/15, 25/25, 50/15, and 50/25 mg.
STORAGE: Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
DOSING: The starting dose is 25/15 mg once daily. The dose may be increased every 6 weeks.
DRUG INTERACTIONS: Captopril may increase potassium levels (hyperkalemia) in blood. Therefore, there is an increased risk of hyperkalemia when captopril is given with potassium supplements or drugs that increase potassium levels (for example, spironolactone [Aldactone]).
Medically Reviewed by a Doctor on 6/17/2015
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