captopril and hydrochlorothiazide, Capozide (cont.)

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Medical and Pharmacy Editor:

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets (captopril/HCTZ): 25/15, 25/25, 50/15, and 50/25 mg.

STORAGE: Tablets should be stored at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Capozide is used to treat high blood pressure. It may be used as initial treatment or substituted for the individual component drugs.

DOSING: The starting dose is 25/15 mg once daily. The dose may be increased every 6 weeks.

DRUG INTERACTIONS: Captopril may increase potassium levels (hyperkalemia) in blood. Therefore, there is an increased risk of hyperkalemia when captopril is given with potassium supplements or drugs that increase potassium levels (for example, spironolactone [Aldactone]).

There have been reports of increased lithium (Eskalith, Lithobid) levels when lithium is used in combination with ACE inhibitors. The reason for this interaction is not known, but the increased levels may lead to toxicity from lithium.

There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors.

Combining captopril or other ACE inhibitors with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.

Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension or low blood pressure) may occur when injectable gold (sodium aurothiomalate), used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors, including captopril. 



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