captopril and hydrochlorothiazide, Capozide

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GENERIC NAME: captopril and hydrochlorothiazide

BRAND NAME: Capozide

DRUG CLASS AND MECHANISM: Capozide is a combination of captopril (Capoten) and hydrochlorothiazide (HCTZ), an angiotensin converting enzyme (ACE) inhibitor and a diuretic (water pill), respectively, and is used in the treatment of high blood pressure. ACE is an enzyme in the body that causes the formation of angiotensin II. Angiotensin II causes the arteries in the body to narrow, thereby elevating blood pressure. ACE inhibitors, such as captopril, lower blood pressure by preventing the formation of angiotensin II thereby relaxing the arteries. HCTZ is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid. It works by blocking salt and fluid reabsorption in the kidneys, causing increased urine output (diuresis). The mechanism of its action in lowering high blood pressure is not well understood. The combination of captopril and HCTZ reduces blood pressure better than either drug alone. Captopril increases potassium levels while HCTZ reduces potassium levels; the combination of both drugs has less effect on potassium levels. The FDA approved captopril/HCTZ in October 1984.




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