capecitabine, Xeloda (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Capecitabine is used for treating women with breast cancer that has spread to other tissues and is resistant to other more commonly-used drugs. It also is used following surgery for later stages of colon cancer and colorectal cancer that has spread to other tissues.
SIDE EFFECTS: The most common side effects with capecitabine are:
Other important side effects experienced by some patients include:
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 150 and 500 mg.
STORAGE: Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
DOSING: The recommended dose is 1250 mg/m2 twice daily, with the two doses approximately 12 hours apart. Tablets should be taken 30 minutes after eating. Capecitabine usually is prescribed in repeated cycles of 3-weeks, with the drug taken for two consecutive weeks followed by a week without drug. Some patients may need lower or delayed dosing if there are side effects.
DRUG INTERACTIONS: Capecitabine increases the blood thinning effect of warfarin (Coumadin) and may increase the risk of bleeding. Capecitabine also may increase blood levels of phenytoin (Dilantin, Dilantin-125), and the dose of phenytoin may need to be reduced.
PREGNANCY: Capecitabine can damage the fetus. It should not be taken by pregnant women.
NURSING MOTHERS: It is not known whether capecitabine is secreted into breast milk.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 5/28/2015
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