capecitabine, Xeloda

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Other important side effects experienced by some patients include:

  • heart attacks,
  • chest pain, and
  • abnormal heart beats.

GENERIC AVAILABLE: No

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 150 and 500 mg.

STORAGE: Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

DOSING: The recommended dose is 1250 mg/m2 twice daily, with the two doses approximately 12 hours apart. Tablets should be taken 30 minutes after eating. Capecitabine usually is prescribed in repeated cycles of 3-weeks, with the drug taken for two consecutive weeks followed by a week without drug. Some patients may need lower or delayed dosing if there are side effects.

DRUG INTERACTIONS: Capecitabine increases the blood thinning effect of warfarin (Coumadin) and may increase the risk of bleeding. Capecitabine also may increase blood levels of phenytoin (Dilantin, Dilantin-125), and the dose of phenytoin may need to be reduced.

PREGNANCY: Capecitabine can damage the fetus. It should not be taken by pregnant women.

NURSING MOTHERS: It is not known whether capecitabine is secreted into breast milk.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 5/28/2015

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