candesartan cilexetil, Atacand (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
STORAGE: Tablets should be stored at room temperature, between 15-30 C (59-86 F).
PRESCRIBED FOR: Candesartan is used alone or in combination with other drugs to treat high blood pressure. It also is used for reducing the chance of death or hospitalization due to heart failure.
DOSING: The recommended dose range of candesartan for adults is 4 to 32 mg once daily. The usual starting dose for hypertension is 16 mg daily, and the starting dose for treating heart failure is 4 mg once daily. Doses may be doubled at 2 week intervals as tolerated by patients. The maximum dose is 32 mg daily.
DRUG INTERACTIONS: Since ARBs can increase the concentrations of potassium in the blood, combining candesartan with other medications that can increase the concentration of potassium in the blood, such as hydrodiuril (Dyazide), spironolactone (Aldactone), and potassium supplements, may lead to dangerous increases in potassium blood levels. Combining candesartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. There have been reports that aspirin and other NSAIDs such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ARBs. An increase in lithium (Eskolith, Lithobid) blood levels has been reported when lithium is combined with candesartan. Careful monitoring of lithium levels is recommended when candesartan and lithium are used concomitantly.
PREGNANCY: When used in the second or third trimester of pregnancy, ARBs can cause injury and even death to the fetus. Candesartan should not be used during pregnancy. When pregnancy is first detected, candesartan should be stopped.
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