candesartan cilexetil, Atacand (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Candesartan is used alone or in combination with other drugs to treat high blood pressure. It also is used for reducing the chance of death or hospitalization due to heart failure.

SIDE EFFECTS: The most common side effects of candesartan are:

Other important side effects include:

Rhabdomyolysis (inflammation and destruction of muscle) and angioedema (swelling of soft tissues including those of the throat and larynx) are rare but serious side effects of candesartan.



PREPARATIONS: Tablets: 4, 8, 16, and 32 mg.

STORAGE: Tablets should be stored at room temperature, between 15-30 C (59-86 F).

DOSING: The recommended dose range of candesartan for adults is 4 to 32 mg once daily. The usual starting dose for hypertension is 16 mg daily, and the starting dose for treating heart failure is 4 mg once daily. Doses may be doubled at 2 week intervals as tolerated by patients. The maximum dose is 32 mg daily.

DRUG INTERACTIONS: Since ARBs can increase the concentrations of potassium in the blood, combining candesartan with other medications that can increase the concentration of potassium in the blood, such as hydrodiuril (Dyazide), spironolactone (Aldactone), and potassium supplements, may lead to dangerous increases in potassium blood levels. Combining candesartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. There have been reports that aspirin and other NSAIDs such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ARBs. An increase in lithium (Eskolith, Lithobid) blood levels has been reported when lithium is combined with candesartan. Careful monitoring of lithium levels is recommended when candesartan and lithium are used concomitantly.

Medically Reviewed by a Doctor on 12/29/2014

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