GENERIC NAME: candesartan cilexetil
BRAND NAME: Atacand
DRUG CLASS AND MECHANISM: Candesartan cilexetil (candesartan) is a drug used for treating high blood pressure (hypertension). It is in a class of drugs called angiotensin receptor blockers (ARBs) which includes losartan (Cozaar), valsartan (Diovan), and irbesartan (Avapro). Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells surrounding blood vessels. Angiotensin's attachment to the receptors causes the muscle cells to contract and the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure. Candesartan blocks the angiotensin receptor and therby prevents the action of angiotensin. As a result blood vessels expand and blood pressure is reduced. Candesartan was approved by the FDA in 1998.
SIDE EFFECTS: The most common side effects of candesartan are:
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