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February 10, 2012

Cancer Prevention Glossary of Terms

The following are health and medical definitions of terms that appear in the Cancer Prevention article.

Adenoma: A benign tumor that arises in or resembles glandular tissue. If it becomes cancerous, it is called an adenocarcinoma.

Arms: An appendage in anatomy and in clinical trials. See: Arm.

Bladder: Any pouch or other flexible enclosure that can hold liquids or gases but usually refers to the hollow organ in the lower abdomen that stores urine -- the urinary bladder. The kidneys filter waste from the blood and produce urine, which enters the bladder through two tubes called ureters. Urine leaves the bladder through another tube, the urethra. In women, the urethra is a short tube that opens just in front of the vagina. In men, it is longer, passing through the prostate gland and then the penis. Infection of the bladder is called cystitis.

Breast cancer: Breast cancer is diagnosed with self- and physician-examination of the breasts, mammography, ultrasound testing, and biopsy. There are many types of breast cancer that differ in their capability of spreading to other body tissues (metastasis). Treatment of breast cancer depends on the type and location of the breast cancer, as well as the age and health of the patient. The American Cancer Society recommends that a woman should have a baseline mammogram between the ages of 35 and 40 years. Between 40 and 50 years of age mammograms are recommended every other year. After age 50 years, yearly mammograms are recommended.

Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily.

Learn more about calcium with evidence-based information on RxList.

Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
See the entire definition of Cancer

Cervical: Having to do with any kind of neck including the neck on which the head is perched and the neck of the uterus. The word "cervix" in Latin means "neck". That is why cervical vertebrae and cervical cancer involve quite disparate parts of the anatomy joined only by the meaning of the word "cervix".

Cervical cancer: Cancer of the entrance to the womb (uterus). The cervix is the lower, narrow part of the uterus (womb). The uterus, a hollow, pear-shaped organ, is located in a woman's lower abdomen, between the bladder and the rectum. The cervix forms a canal that opens into the vagina, which leads to the outside of the body.

Regular pelvic exams and Pap testing can detect precancerous changes in the cervix. Precancerous changes in the cervix may be treated with cryosurgery, cauterization, or laser surgery. The most common symptom of cancer of the cervix is abnormal bleeding. Cancer of the cervix can be diagnosed using a Pap test or other procedures that sample the cervix tissue. Cancer of the cervix requires different treatment than cancer that begins in other parts of the uterus.
See the entire definition of Cervical cancer

Chemoprevention: The use of natural or laboratory-made substances to prevent a disease such as cancer. The regular use of aspirin is known to reduce the risk of the polyps from which colorectal cancer arises. This is an instance of chemoprevention.
See the entire definition of Chemoprevention

Colon: The part of the large intestine that runs from the cecum to the rectum as a long hollow tube that serves to remove water from digested food and let the remaining material, solid waste called stool, move through it to the rectum and leave the body through the anus. .
See the entire definition of Colon

Colon cancer: A malignancy that arises from the inner lining of the colon. Most, if not all, of these cancers develop from colonic polyps. Removal of these precancerous polyps can prevent colon cancer.
See the entire definition of Colon cancer

Cox-2: Cyclooxygenase-2, a protein acts as an enzyme and specifically catalyzes (speeds) the production of certain chemical messengers called prostaglandins. Some of these messengers are responsible for promoting inflammation. When Cox-2 activity is blocked, inflammation is reduced. Unlike cox-1, cox-2 is active only at the site of inflammation, not in the stomach.

Cyclooxygenase: Abbreviated cox. See: Cox-1; Cox-2.

Cytology: The medical and scientific study of cells. Cytology refers to a branch of pathology, the medical specialty that deals with making diagnoses of diseases and conditions through the examination of tissue samples from the body.
See the entire definition of Cytology

Enzymes: Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.
See the entire definition of Enzymes back to top

Esophageal: Pertaining to the esophagus.

Estrogen: Estrogen is a female hormone produced by the ovaries. Estrogen deficiency can lead to osteoporosis.
See the entire definition of Estrogen

Estrogens: Female hormones produced by the ovaries. Estrogen deficiency can lead to osteoporosis.
See the entire definition of Estrogens

Excision: 1. Surgical removal, as in the excision of a tumor. 2. The removal as if by surgery, as in base excision repair.
See the entire definition of Excision

Exogenous: Originating from outside the organism. Insulin taken by a diabetic is exogenous insulin.

Fecal: Relating to the feces, the stool. The excrement discharged from the intestines.
See the entire definition of Fecal

Fiber: The parts of plants that cannot be digested, namely complex carbohydrates. Also known as bulk or roughage.
See the entire definition of Fiber

Folic acid: One of the B vitamins that is a key factor in the synthesis (the making) of nucleic acid (DNA and RNA).
See the entire definition of Folic acid

Gene: The basic biological unit of heredity. A segment of deoxyribonucleic acid (DNA) needed to contribute to a function.
See the entire definition of Gene

Genetic: Having to do with genes and genetic information.

Genetic testing: Tests done for clinical genetic purposes. Genetic tests may be done for diverse purposes pertaining to clinical genetics, including the diagnosis of genetic disease in children and adults; the identification of future disease risks; the prediction of drug responses; and the detection of risks of disease to future children.

In situ: In the normal location. An "in situ" tumor is one that is confined to its site of origin and has not invaded neighboring tissue or gone elsewhere in the body.
See the entire definition of In situ

Incidence: The frequency with which something, such as a disease, appears in a particular population or area. In disease epidemiology, the incidence is the number of newly diagnosed cases during a specific time period. The incidence is distinct from the prevalence which refers to the number of cases alive on a certain date.

Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
See the entire definition of Infection

Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."

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Lung cancer: Cancer of the major organ of respiration - the lung. Lung cancer kills more men and women than any other form of cancer. Since the majority of lung cancer is diagnosed at a relatively late stage, only 10% of all lung cancer patients are ultimately cured. Eight out of 10 lung cancers are due to tobacco smoke. Lung cancers are classified as either small cell or non-small cell cancers. Persistent cough and bloody sputum can be symptoms of lung cancer. Lung cancer can be diagnosed based on examination of sputum, or tissue examination with biopsy using bronchoscopy, needle through the chest wall, or surgical excision.

Mortality: A fatal outcome or, in one word, death. The word "mortality" is derived from "mortal" which came from the Latin "mors" (death). The opposite of mortality is, of course, immortality. Mortality is also quite distinct from morbidity (illness).
See the entire definition of Mortality

Neck: The part of the body joining the head to the shoulders. Also, any narrow or constricted part of a bone or organ that joins its parts as, for example, the neck of the femur bone.

Occult: Hidden.
See the entire definition of Occult

Overweight: The term "overweight" is used in two different ways. In one sense it is a way of saying imprecisely that someone is heavy. The other sense of "overweight" is more precise and designates a state between normal weight and obesity.
See the entire definition of Overweight

Pap Smear: A screening test for cervical cancer based on the examination under the microscope of cells collected from the cervix, smeared on a slide and specially stained to reveal premalignant (before cancer) and malignant (cancer) changes as well as changes due to noncancerous conditions such as inflammation from infections.
See the entire definition of Pap Smear

Placebo: A "sugar pill" or any dummy medication or treatment.
See the entire definition of Placebo

Precancerous: Pertaining to something that is not yet overtly cancerous, but appears to be on its way to becoming a cancer. Synonymous with premalignant.

Prevalence: The proportion of individuals in a population having a disease. Prevalence is a statistical concept referring to the number of cases of a disease that are present in a particular population at a given time.

Proinflammatory: Capable of promoting inflammation. For example, air pollution may have proinflammatory effects.

Prophylactic: A preventive measure. The word comes from the Greek for "an advance guard," an apt term for a measure taken to fend off a disease or another unwanted consequence.
See the entire definition of Prophylactic

Prostate: A gland within the male reproductive system that is located just below the bladder. Chestnut shaped, the prostate surrounds the beginning of the urethra, the canal that empties the bladder.
See the entire definition of Prostate

Prostate cancer: An uncontrolled (malignant) growth of cells in the prostate gland which is located at the base of the urinary bladder and is responsible for helping control urination as well as forming part of the semen. Prostate cancer is the second leading cause of death of males in the U.S.

Radiation: 1. Rays of energy. Gamma rays and X-rays are two of the types of energy waves often used in medicine. 2. The use of energy waves to diagnose or treat disease. See also: Irradiation.

Randomized: The use of chance alone to assign the participants in an experiment or trial to different groups in order to fairly compare the outcomes with different treatments. Randomization is an important feature of experimental design.

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Randomized controlled trial: (RCT) A study in which people are allocated at random (by chance alone) to receive one of several clinical interventions. One of these interventions is the standard of comparison or control. The control may be a standard practice, a placebo ("sugar pill"), or no intervention at all. Someone who takes part in a randomized controlled trial (RCT) is called a participant or subject. RCTs seek to measure and compare the outcomes after the participants receive the interventions. Because the outcomes are measured, RCTs are quantitative studies.
See the entire definition of Randomized controlled trial

Receptor: 1. In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are many receptors. There is a receptor for (insulin; there is a receptor for low-density lipoproteins (LDL); etc. To take an example, the receptor for substance P, a molecule that acts as a messenger for the sensation of pain, is a unique harbor on the cell surface where substance P docks. Without this receptor, substance P cannot dock and cannot deliver its message of pain. Variant forms of nuclear hormone receptors mediate processes such as cholesterol metabolism and fatty acid production. Some hormone receptors are implicated in diseases such as diabetes and certain types of cancer. A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions.
2. In neurology, a terminal of a sensory nerve that receives and responds to stimuli.

Recurrence: The return of a sign, symptom or disease after a remission. The reappearance of cancer cells at the same site or in another location is, unfortunately, a familiar form of recurrence.
See the entire definition of Recurrence

Selenium: An essential trace mineral that functions largely in the form of proteins, called selenoproteins, which act as enzymes and help prevent damage to cells in the body by oxidants in the environment or those produced by normal metabolism.
See the entire definition of Selenium

Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
See the entire definition of Surgery

Synthesis: Putting together different entities to make a whole which is new and different. In biochemistry, synthesis refers specifically to the process of building compounds from more elementary substances by means of one or more chemical reactions.
See the entire definition of Synthesis

Therapy: The treatment of disease.
See the entire definition of Therapy

Tobacco: A South American herb, formally known as Nicotiana tabacum, whose leaves contain 2-8% nicotine and serve as the source of smoking and smokeless tobacco.
See the entire definition of Tobacco

Ultraviolet radiation: Invisible rays that are part of the energy that comes from the sun. Ultraviolet radiation can burn the skin and cause skin cancer.
See the entire definition of Ultraviolet radiation

Urinary: Having to do with the kidneys, ureters, and bladder. The urinary system represents the functional and anatomic aspects of the kidneys, ureters, and bladder.

Vaccines: Microbial preparations of killed or modified microorganisms that can stimulate an immune response in the body to prevent future infection with similar microorganisms. These preparations are usually delivered by injection.

Vitamin E: Alpha-tocopherol, an antioxidant vitamin which binds oxygen free radicals that can cause tissue damage. Deficiency of vitamin E can lead to anemia. Vitamin E may play a possible role in preventing heart disease and cancer of the lung and prostate.
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  • Related Diseases & Conditions

    • Anemia
      • Anemia is the condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased.
    • Skin Cancer
      • Skin cancer is the most common form of cancer in humans. There are three main types of skin cancer; basal cell carcinoma and squamous cell carcinoma (the nonmelanoma skin cancers), and melanoma.
    • Cervical Cancer
      • Cervical cancer is cancer of the entrance to the womb (uterus). Regular pelvic exams and Pap testing can detect precancerous changes in the cervix. Precancerous changes in the cervix may be treated with cryosurgery, cauterization, or laser surgery. The most common symptom of cancer of the cervix is abnormal bleeding.
    • Oral Cancer
      • The term oral cancer includes cancer of the mouth (oral cavity) and the back of the mouth (oropharynx). Red and white patches inside the mouth, bleeding, loose teeth, pain upon swallowing, a lump in the neck, earache, and a sore on your lip or in your mouth that won't heal are all symptoms of oral cancer. Treatment for oral cancer depends upon the staging of the disease and usually involves surgery, radiation therapy, or chemotherapy.
    • Melanoma
      • Melanoma is a type of skin cancer which begins in skin cells called melanocytes and affects more than 53,600 people in the United States each year. These melanocytes can grow together to form benign moles which, after a change in size, shape, or color can be a sign of melanoma. Caused by sun exposure, early detection becomes extremely important to avoid a spread to other areas of the body. Diagnosis is confirmed through a biopsy of the abnormal skin and treatment depends on the extent and characteristics of the patient.
    • Vaginal Bleeding
      • Normal vaginal bleeding (menorrhea) occurs through the process of menstruation. Abnormal vaginal bleeding in women who are ovulating regularly most commonly involves excessive, frequent, irregular, or decreased bleeding. Causes of abnormal may arise from a variety of conditions.
    • Blood in Urine
      • Blood in the urine is termed hematuria. Hematuria, whether it be gross or microscopic, is abnormal and should be further investigated.
    • Prostate Cancer
      • Prostate cancer is an uncontrolled (malignant) growth of cells in the prostate gland. Prostate cancer is the second leading cause of death of males in the U.S. Prostate cancer is often initially suspected because of an abnormal PSA blood test or a hard nodule (lump) felt on the prostate gland during a routine rectal examination.
    • Cervical Dysplasia
      • Cervical dysplasia is a condition in which the cells of the inner lining of the cervix have precancerous changes. There are two types of cervical dysplasia; 1) squamous intraepithelial lesion, and 2) cervical intraepithelial neoplasia. Cervical dysplasia is caused by infection of the cervix with HPV (human papillomavirus). There are various diagnostic measures for cervical dysplasia. Treatment generally depends upon the progression of the dysplasia, mild, moderate, or severe.
    • Colon Polyps
      • A colon polyp is a benign tumor of the large intestine. Benign polyps do not invade nearby tissue or spread to other parts of the body. Benign polyps can easily be removed during colonoscopy and are not life threatening. If benign polyps are not removed from the large intestine, they can become malignant over time.
    • Barrett's Esophagus
      • Barrett's esophagus occurs as a complication of chronic gastroesophageal reflux disease (GERD), primarily in white males. GERD refers to the reflux of acidic fluid from the stomach into the esophagus (the swallowing tube), and is classically associated with heartburn.
    • Breast Lumps (In Women)
      • Breast lumps in women can have a variety of causes such as breast inflammation, infection, injuries, cancer, and non-cancerous growths. Breast lumps in women are diagnosed with physical exam, mammogram, ultrasound, MRI, and biopsy. Treatment of breast lumps in women depend on the cause.
    • Smoking (How to Quit Smoking)
      • Smoking is an addiction. More than 430,000 deaths occur each year in the U.S. from smoking related illnesses. Secondhand smoke or "passive smoke" also harm family members, coworkers, and others around smokers. There are a number of techniques available to assist people who want to quit smoking.
    • Male Breast Cancer
      • Male breast cancer accounts for 1% of all breast cancers, and most cases are found in men between the ages of 60 and 70. A man's risk of developing breast cancer is one in 1,000. Signs and symptoms include a firm mass located below the nipple and skin changes around the nipple, including puckering, redness or scaling, retraction and ulceration of the nipple. Treatment depends upon staging and the health of the patient.
    • Freckles
      • Freckles are flat circular spots on the skin that may be red, yellow, tan, light brown, brown, or black in color. Lentigo is the term used to describe certain types of darker freckles. Ephelis typically appear during the sunny months. Freckles can be prevented with sunscreens, the use of wide-brimmed hats, sun-protective clothing, avoiding peak sun hours, and seeking shade and staying indoors.
    • Cancer Risk Factors
      • Though it's difficult to say why some people develop cancer while others don't, research shows that certain risk factors increase a person's odds of developing cancer. These risk factors include growing older, family history of cancer, diet, alcohol and tobacco use, and exposure to sunlight, ionizing radiation, certain chemicals, and some viruses and bacteria.
    • Sun-Sensitive Drugs (Photosensitivity to Drugs)
      • Sun sensitivity (photosensitivity) is an inflammation of the skin induced by the combination of medications or substances and sunlight. The affect on the skin is redness, which looks similar to a sunburn. Generally, these reactions are either phototoxic or photoallergic. Phototoxic drugs are more common than photoallergic drugs. Symptoms of phototoxic reactions are a burning and stinging sensation and then redness. Symptoms of photoallergic reactions are itching, redness, swelling, blisters of the affected area. Treatment generally is discontinuation of the medication and topical application of creams.
    • Sunburn (Sun Poisoning)
      • Sunburn is caused by overexposure to UV radiation from the sun. UV rays can also damage the eyes. Repeated overexposure to UV rays also increases the risk for scarring, freckles, wrinkles, and dry skin. Symptoms of sunburn include painful, red, tender, and hot skin. The skin may blister, swell, and peel. Sun poisoning (severe sunburn) include nausea, fever, chills, rapid pulse, dizziness and more. Treatment for sunburn depends upon the severity. Sun protection and sunscreen for an individual's skin type is recommended to decrease the chance of sunburn.
    • Asbestos
      • Asbestos exposure lung disease is divided into three main types, asbestosis (lung scarring caused by asbestos fibers), disease of the lining of the lung (pleural plaques, scarring, or fluid accumulation), and lung cancer. Mesothelioma is cancer of the lining of the lung caused by asbestos exposure. Cancers of the larynx, throat, kidney, esophagus, and gallbladder have been linked to asbestos exposure. Treatment is dependant upon the type of condition related to asbestos exposure.
    • Breast Cancer Prevention
      • Lifestyle changes, a healthy antioxidant-rich diet, exercise, and weight reduction can help reduce a woman's risk of developing breast cancer. It's important to be aware of how risk factors such as family history, lifestyle factors, breast conditions, radiation therapy, and hormonal factors may influence your chances of developing breast cancer. Mammography and breast self-examinations are crucial steps in breast cancer prevention.
    • Smokeless Tobacco
      • Smokeless tobacco can have negative health effects such as cancers, poor oral health (gum disease and tooth decay), infertility, pregnancy complications, and nicotine addiction.
    • Healthy Living & Disease Prevention
      • The importance of a healthy lifestyle in disease prevention is widely understood and most people know that lifestyle changes and choices can be critical to good health. Yet, few practice healthy behaviors that constitute healthy living.
    • Colon Cancer Prevention
    • Disease Prevention in Men
      • Disease prevention in men includes routine screening tests that are part of basic prevention medicine. Take an active role in your own health care and discuss screening tests with your doctor early in life. Age of screening and timing of screening depends upon the condition being assessed.
    • Disease Prevention in Women
      • Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests are commonly available through your general doctor. Some specialized tests may be available elsewhere.
    • Endometrial Cancer Prevention
      • Endometrial cancer, or uterine cancer, affects the endometrium of the uterus. It's the most common invasive cancer of the female reproductive system. Risk factors include smoking, obesity, lack of exercise, taking estrogen-only hormone therapy, early menstruation, late menopause, and never being pregnant.
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Cancer Prevention

What is a fecal occult blood test?

Fecal occult blood testing (FOBT) is testing that is performed on samples of stool in order to detect occult blood (blood that is not visible to the naked eye) in otherwise normal-colored stool. Fecal occult blood usually is a result of slow (often intermittent) bleeding from inside the upper or lower gastrointestinal tract. The slow bleed does not change the color of the stool or result in visible bright red blood, and hence the blood is found only by testing the stool for blood in the laboratory. Occult bleeding has many of the same causes as other forms of more rapid gastrointestinal bleeding such as rectal bleeding (passage of red blood and/or blood clots rectally) and melena (black tarry stool as a result of bleeding from the upper intestines such as ulcers). Please read the Rectal Bleeding article for a more detailed explanation of different patterns of gastrointestinal bleeding.

Why is fecal occult blood testi...

Read the Fecal Occult Blood Test article »




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