GENERIC NAME: canagliflozin
BRAND NAME: Invokana
DRUG CLASS AND MECHANISM: Canagliflozin is an oral drug that reduces blood sugar (glucose) levels in patients with type 2 diabetes. It is a new type of diabetes medication in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Under normal conditions, glucose is filtered out of the blood and into the kidney tubules as blood passes through the kidneys. The glucose then as absorbed from the tubules back into the blood so that glucose is not lost in the urine. SGLT2 is an enzyme in the kidney tubule that causes glucose to be reabsorbed from urine. Canagliflozin blocks the action of SGLT2. Therefore, canagliflozin reduces the reabsorption of glucose from renal tubules, leading to more excretion of glucose in urine. Canagliflozin was approved by the FDA in March 2013.
SIDE EFFECTS AND PRECAUTIONS: The most common side effects of canagliflozin are:
Other side effects of canagliflozin include:
- low blood pressure,
- increased potassium blood levels (hyperkalemia),
- low blood sugar (hypoglycemia), and
- increased cholesterol.
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