calcitriol (Rocaltrol)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

View the Fat-Fighting Foods Slideshow
>

DRUG INTERACTIONS:

Calcitriol should not be used with other vitamin D products because of the increased risk of additive side effects and toxicity.

Cholestyramine (Questran), colestipol (Colestid), mineral oil, and orlistat (Alli, Xenical) may decrease the intestinal absorption of calcitriol. Separating the administration of these medications and calcitriol may prevent this interaction.

Phenytoin (Dilantin) and phenobarbital (Luminal) may reduce blood concentrations of calcitriol, decreasing treatment effectiveness. Higher doses of calcitriol may be necessary if these drugs are used together with calcitriol.

Thiazide diuretics may increase the blood levels of calcium. Since calcitriol also increases calcium levels, taking these two types of medications together may cause hypercalcemia (abnormally highly levels of calcium).

Calcitriol should be used cautiously in patients taking digoxin (Lanoxin). High levels of calcium may cause symptoms of digoxin toxicity such as irregular heartbeats.

Ketoconazole (Nizoral) may decrease the activity of enzymes responsible for metabolizing or breaking down calcitriol and lead to the side effects of excessive vitamin D.

Magnesium containing medications (for example, antacids) should be avoided in patients undergoing chronic renal dialysis who are taking calcitriol. These patients are at high risk of experiencing hypermagnesemia (high blood levels of magnesium) as their kidneys are unable to remove adequate amounts of magnesium from the blood.

PREGNANCY: There are no adequate and well-controlled studies of calcitriol treatment in pregnant women. Calcitriol should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby.

NURSING MOTHERS: Calcitriol may be excreted in human milk. Mothers should not breastfeed while taking calcitriol.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 10/7/2015

Quick GuidePortion Control Tips: Lose Weight and Stick to Your Diet

Portion Control Tips: Lose Weight and Stick to Your Diet
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Weight Loss/Healthy Living Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors