- What is calcitriol-oral, and how does it work (mechanism of action)?
- What brand names are available for calcitriol-oral?
- Is calcitriol-oral available as a generic drug?
- Do I need a prescription for calcitriol-oral?
- What are the side effects of calcitriol-oral?
- What is the dosage for calcitriol-oral?
- Which drugs or supplements interact with calcitriol-oral?
- Is calcitriol-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about calcitriol-oral?
What is the dosage for calcitriol-oral?
- The recommended initial oral dose for treating low calcium due to kidney dialysis is 0.25 mcg daily.
- The dose may be increased by 0.25 mcg daily every 4 to 8 weeks.
- Most patients respond to 0.5 to 1 mcg daily.
- The oral dose for treating hypoparathyroidism is 0.25 mcg to 2 mcg daily.
Which drugs or supplements interact with calcitriol-oral?
Calcitriol should not be used with other vitamin D products because of the increased risk of additive side effects and toxicity.
Cholestyramine (Questran), colestipol (Colestid), mineral oil, and orlistat (Alli, Xenical) may decrease the intestinal absorption of calcitriol. Separating the administration of these medications and calcitriol may prevent this interaction.
Phenytoin (Dilantin) and phenobarbital (Luminal) may reduce blood concentrations of calcitriol, decreasing treatment effectiveness. Higher doses of calcitriol may be necessary if these drugs are used together with calcitriol.
Thiazide diuretics may increase the blood levels of calcium. Since calcitriol also increases calcium levels, taking these two types of medications together may cause hypercalcemia (abnormally highly levels of calcium).
Calcitriol should be used cautiously in patients taking digoxin (Lanoxin). High levels of calcium may cause symptoms of digoxin toxicity such as irregular heartbeats.
Ketoconazole (Nizoral) may decrease the activity of enzymes responsible for metabolizing or breaking down calcitriol and lead to the side effects of excessive vitamin D.
Magnesium containing medications (for example, antacids) should be avoided in patients undergoing chronic renal dialysis who are taking calcitriol. These patients are at high risk of experiencing hypermagnesemia (high blood levels of magnesium) as their kidneys are unable to remove adequate amounts of magnesium from the blood.
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