calcitonin (cont.)

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Paget's disease is a bone disease characterized by a disorderly and accelerated remodeling of the bone, leading to bones that are weak and painful. Calcitonin reduces the turnover of bone and pain in patients with Paget's disease. The FDA approved calcitonin intranasal spray in March, 1991.



PREPARATIONS: Injection: 200 units/ml. Intranasal spray: 200 units/activation (0.09 ml/puff)

STORAGE: Calcitonin should be stored in a refrigerator between 2-8 C (36-46 F). It should be protected from freezing. Bottles of intranasal spray that are being used may be stored at room temperature between 15 C-30 C (59 F-86 F) for 30 days.

PRESCRIBED FOR: Injectable calcitonin is used to treat osteoporosis and Paget's disease. Injectable calcitonin also is used to treat seriously elevated blood calcium levels. The nasal spray is used only for osteoporosis in women who are at least 5 years postmenopausal.

DOSING: Injectable calcitonin is injected under the skin or into the muscle. The nasal spray is administered into the nostril. To achieve optimal results, patients with osteoporosis should simultaneously receive adequate amounts of calcium and vitamin D.

The recommended regimens for Paget's disease and postmenopausal osteoporosis are 100 units per day injected into muscle or under the skin. Postmenopausal osteoporosis can also be treated with 1 spray (200 units) per day administered in alternate nostrils. Increased blood calcium (hypercalcemia) is treated with 4-8 units/kg of injectable calcitonin every 6-12 hours

DRUG INTERACTIONS:  Combining calcitonin salmon and lithium may reduce lithium concentrations due to increased loss of lithium in urine. The dose of lithium may require adjustment.PREGNANCY: There are no adequate studies of calcitonin in pregnant women.

NURSING MOTHERS: There are no adequate studies of calcitonin in nursing mothers.

SIDE EFFECTS: Side effects from calcitonin are uncommon and usually are mild. Injectable calcitonin can cause nausea with or without vomiting in 10% of patients. Nausea can occur with initial treatment and tends to disappear with continued use. Injectable calcitonin also can cause local redness of the skin at the site of injection. Flushing and skin rash are also seen. The nasal spray can cause runny nose (rhinorrhea), nose-bleeding, bone pain and headaches. The nausea that can occur with injectable calcitonin is unlikely to occur with the nasal spray. In rare instances, the nasal spray can cause an upset stomach.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 10/8/2014

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