caffeine (Enerjets, No Doz, Vivarin)

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GENERIC NAME: caffeine (oral)

BRAND NAMES: Enerjets, No Doz, Vivarin

DRUG CLASS AND MECHANISM: Caffeine acts as a stimulant of the nervous system by inhibiting the enzyme phosphodiesterase, just like theophylline and aminophylline. Inhibiting this enzyme leads to increased formation of the proteins which causes release of stimulating chemical signals known as neurotransmitters. These neurotransmitters bind to various sites in the body, including the brain, heart, and muscles to cause a stimulant effect.



PREPARATIONS: Tablets: 200 mg; Lozenge: 75mg

STORAGE: Caffeine should be stored at room temperature, between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Oral caffeine tablets are used to restore mental alertness or wakefulness when experiencing fatigue and drowsiness and caffeine withdrawal.

DOSING: 100 to 200 mg every 3 to 4 hours as needed no later than 6 hours before bedtime.

DRUG INTERACTIONS: Combining caffeine with other stimulating agents, such as methylphenidate (Ritalin, Ritalin SR, Ritalin LA, Concerta, Methylin, Methylin ER, Metadate CD, Metadate ER), should be done with caution. This combination may cause increased side effects including rapid heartbeat, high blood pressure, hallucinations, tremor, and anxiety. Other dietary sources of caffeine, such as tea, add to the effect. Caffeine should be used with caution with adenosine, as the effects of adenosine may be diminished. Linezolid, phenelzine, selegiline, and tranylcypromine combined with caffeine increases the risk of high blood pressure. Consider alternatives when combining caffeine and vemurafenib and Stiripentol as caffeine concentrations may be increased.

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