butorphanol (Stadol) (cont.)

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STORAGE: Butorphanol solution should be stored at room temperature, between 15 C to 30 C (59 F to 86 F) and protected from light. Nasal spray should be stored at room temperature between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Butorphanol is prescribed for the treatment of pain that is severe enough to require an opioid, as well as for preoperative or preanesthetic pain management. It is also used to supplement balanced anesthesia and manage pain during labor.

DOSING: The initial dose for adults is based on the setting in which it is used, as well as whether it is delivered intramuscularly, intravenously, or through nasal spray. Most initial intravenous doses for pain range between 0.5 to 2 mg, which may be repeated every 3 to 4 hours as needed.

DRUG INTERACTIONS: Combining butorphanol with other agents that cause depression of the central nervous system may lead to increased sedation and confusion.

Alvimopan (Entereg) should not be combined with butorphanol because it increases levels of butorphanol.

Butorphanol should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase, for example, linezolid (Zyvox). Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Butorphanol should not be administered within 14 days of stopping an MAOI.

Medically Reviewed by a Doctor on 8/12/2014

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