butorphanol (Stadol)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

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GENERIC NAME: butorphanol

BRAND NAMES: Stadol

DRUG CLASS AND MECHANISM: Butorphanol is a synthetic opioid narcotic pain reliever. It prevents pain in a similar way as morphine (MS Contin), hydrocodone (Zohydro), oxycodone (Oxycontin), and other opioids. Like other opioids, it stimulates receptors in the brain to increase the threshold to pain (the amount of stimulation it takes to feel pain) and reduce the perception of pain (the perceived importance of the pain). The FDA approved butorphanol in August 1978.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Solution with or without preservatives: 1 or 2 mg/mL in 1, 2, 10 mL; Nasal solution: 10 mg/ mL in 2.5 mL bottle.

STORAGE: Butorphanol solution should be stored at room temperature, between 15 C to 30 C (59 F to 86 F) and protected from light. Nasal spray should be stored at room temperature between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Butorphanol is prescribed for the treatment of pain that is severe enough to require an opioid, as well as for preoperative or preanesthetic pain management. It is also used to supplement balanced anesthesia and manage pain during labor.

DOSING: The initial dose for adults is based on the setting in which it is used, as well as whether it is delivered intramuscularly, intravenously, or through nasal spray. Most initial intravenous doses for pain range between 0.5 to 2 mg, which may be repeated every 3 to 4 hours as needed.

DRUG INTERACTIONS: Combining butorphanol with other agents that cause depression of the central nervous system may lead to increased sedation and confusion.

Medically Reviewed by a Doctor on 8/12/2014

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