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busulfan - oral, Myleran (cont.)

USES: Busulfan is used to treat chronic myelogenous leukemia (CML). It does not cure the disease but helps to control it so that your quality of life is improved.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used as a pretreatment for patients who are undergoing stem cell transplant.

HOW TO USE: Take this medication by mouth with or without food, usually once daily or as directed by your doctor.Dosage is based on your weight, medical condition, laboratory test results, and response to treatment. Your treatment may be stopped for a short time if your blood counts are too low. Keep all medical and laboratory appointments.Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.Tell your doctor if your condition does not improve or if it worsens.

SIDE EFFECTS: See also Warning section.Darkening skin or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Many people using this medication develop serious side effects. However, your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.Tell your doctor immediately if any of these unlikely but serious side effects occur: signs of liver disease (such as persistent nausea/vomiting, severe stomach/abdominal pain, yellowing skin/eyes, dark urine), missed menstrual periods, shrinking testicles, seizures, unusual/extreme tiredness, painful urination, toe/joint pain.Tell your doctor immediately if any of these rare but serious side effects occur: fainting, fast/pounding heartbeat, cloudy/blurred vision.Busulfan has rarely caused very serious (possibly fatal) lung disease. This may occur after months to years of using busulfan. Tell your doctor immediately if you develop symptoms of lung disease, including chest pain, shortness of breath, persistent cough.Busulfan may cause other cancers (such as acute leukemia, tumors). Consult your doctor for more details. Tell your doctor immediately if you notice any symptoms of cancer, including unusual lumps, sudden weight loss.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.



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