busulfan-injection (cont.)
PRECAUTIONS: Tell your doctor your medical history, especially of: seizures, head injury, blood disorders (thalassemia), diabetes, lung disease, serious infections, any allergies you may have. Because this medication can lower your body's ability to fight an infection, do not touch your eyes or the inside of your nose without first washing your hands. Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine. Use caution with sharp objects like safety razors or nail cutters, and avoid activities that might cause injury. Caution is advised when using this drug in children because they may clear the drug from their system faster, and therefore may require special dosing and monitoring. This drug may also cause fertility problems. This medication is not recommended for use during pregnancy. Busulfan may cause fetal harm. Avoid becoming pregnant while using this drug. Consult your doctor for more details. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Tell your doctor or pharmacist of all prescription and nonprescription drugs you may use, especially of: azole antifungals (e.g., itraconazole,), thioguanine, acetaminophen, drugs that can cause seizures (e.g., bupropion), drugs that can increase seizure risk (e.g., phenothiazines such as chlorpromazine), other drugs which affect the bone marrow/immune system (e.g., other anti-cancer drugs, cyclosporine). Check your prescription and nonprescription labels carefully for acetaminophen-containing products. If needed, use the products cautiously 3 days before and during therapy with busulfan. Acetaminophen may increase busulfan blood levels and side effects. If acetaminophen is used, do not exceed recommended daily doses. Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include severe fatigue, persistent sore throat, fever; or easy bruising or bleeding.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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