buspirone, Buspar (Discontinued brand in the US) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Buspirone is used for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Buspirone is especially effective in persons with generalized anxiety of a limited or moderate degree. It is not very effective in persons with severe anxiety, panic disorders, or obsessive-compulsive disorders. It also may help improve symptoms of depression in patients with generalized anxiety disorder.

SIDE EFFECTS: The most common side effects associated with buspirone are:

Other important but less frequent side effects include



PREPARATIONS: Tablets: 5, 10, 15 and 30 mg.

STORAGE: Tablets should be kept at room temperature, less than 30 C (86 F).

DOSING: The usual starting adult dose is 10-15 mg daily given in 2 or 3 doses. The dose may be increased by 5 mg every 2 to 4 days until an effective dose is found. The maximum adult dose is 60 mg daily, but most patients respond to 15-30 mg daily. Although food increases the amount of buspirone that is absorbed, the importance of this effect is not clear. Buspirone can be taken with or without food but preferably on a consistent basis.

DRUG INTERACTIONS: Buspirone may interact with drugs called monoamine oxidase (MAO) inhibitors, such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) which are used in psychiatric disorders. The use of buspirone with these drugs can cause increased blood pressure. A similar reaction may occur if buspirone is combined with linezolid (Zyvox), an antibiotic that is also an MAO inhibitor. The combination of buspirone and trazodone (Desyrel), an antidepressant, may cause abnormal liver enzymes in the blood.

Medically Reviewed by a Doctor on 9/10/2015

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