DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine, procarbazine, selegiline, isocarboxazid, tranylcypromine). If you are currently using or have recently stopped taking an MAO inhibitor within the last 14 days, tell your doctor or pharmacist before starting bupropion. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: adrenaline-like stimulants (e.g., ephedrine), amantadine, diabetes medications (e.g., hypoglycemic agents such as glyburide, glipizide, or insulin), levodopa, products containing nicotine (e.g., patches, gum, or spray), regular use of sedatives (e.g., diazepam), ritonavir, warfarin. Also tell your doctor if you are taking any drugs which are affected by certain liver enzymes (CYP 2D6 or CYP 2B6 substrates, inhibitors, or inducers), such as certain SSRI antidepressants (e.g., paroxetine, fluoxetine, sertraline), beta-blockers (e.g., metoprolol), antiarrhythmics (e.g., propafenone, flecainide), orphenadrine, thiotepa, cyclophosphamide, carbamazepine, phenobarbital, phenytoin, valproic acid. Report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with bupropion such as phenothiazines (e.g., thioridazine), tricyclic antidepressants (e.g., amitriptyline), isoniazid (INH), or theophylline among others. Consult your doctor or pharmacist for details. Excess caffeine intake can increase the chance of seizures with this drug. Check all nonprescription/prescription drug labels for caffeine. Consult your doctor or pharmacist. Do not start or stop any medicine without doctor or pharmacist approval.

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