bupropion hydrochloride extended release (Forfivo XL) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:


GENERIC AVAILABLE: Yes (other extended release formulations of bupropion)


  • Tablets: 75, 100, and 150 mg.
  • Sustained Release tablets: 100, 150 and 200 mg.
  • Extended Release tablets: 150 and 300 mg.

STORAGE: Tablets should be kept at room temperature, 15 C to 25 C (59 F to 77 F).

PRESCRIBED FOR: Bupropion is used for the management of major depression.

DOSING: Bupropion is given as 450 mg once daily without regards to meals. It is given to patients receiving 300 mg of another bupropion formulation daily for at least 2 weeks and require 450 mg daily. Those receiving 450 mg daily of another bupropion formulation can be switched directly to Forfivo.

DRUG INTERACTIONS: Bupropion should be used cautiously in patients receiving drugs that reduce the threshold for seizures. Such drugs include prochlorperazine (Compazine), chlorpromazine (Thorazine), and other antipsychotic medications of the phenothiazine class. Additionally, persons who are withdrawing from benzodiazepines (for example, diazepam [Valium], alprazolam [Xanax]) are at increased risk for seizures.

Carbamazepine (Tegretol) may reduce the effect of bupropion by reducing its blood concentration. Monamine oxidase inhibitors should not be combined with bupropion because of the risk of severe reactions. At least 14 days should elapse between discontinuation of an monoamine oxidase inhibitor and initiation of bupropion. bupropion may affect the action of warfarin (Coumadin).

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index