DRUG INTERACTIONS: Bupropion should be used cautiously in patients receiving drugs that reduce the threshold for seizures. Such drugs include prochlorperazine (Compazine), chlorpromazine (Thorazine}, and other antipsychotic medications of the phenothiazine class. Additionally, persons who are withdrawing from benzodiazepines (for example, diazepam [Valium], alprazolam [Xanax]) are at increased risk for seizures.
Carbamazepine (Tegretol) may reduce the effect of bupropion by reducing the blood concentration of bupropion. Monamine oxidase inhibitors (MAOIs) antidepressants should not be combined with bupropion because of the risk of severe reactions. At least 14 days should elapse between discontinuation of an MAOI and initiation of bupropion.
Quick GuideDepression Hurts: Physical Symptoms of Depression
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