bupropion, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL (cont.)

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Medical and Pharmacy Editor:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

Extended Release tablets: 150, and 174, 300, 348, 450, 522 mg.

STORAGE: Tablets should be kept at room temperature, 15 C to 25 C (59 F to 77 F).

PRESCRIBED FOR: Bupropion is used for the management of major depression and seasonal affective disorder (depression that occurs primarily during the fall and winter). It is also prescribed for smoking cessation.

DOSING: Bupropion immediate release tablets are usually is given in one, two or three daily doses. For immediate-release tablets, no single dose should exceed 150 mg and each dose should be separated by 6 hours.

For depression, the recommended dose of immediate-release tablets is 100 mg 3 times daily (300 mg/day) maximum dose is 450 mg daily. The initial dose is 100 mg twice daily. The dose may be increased to 100 mg 3 times daily after three days and 150 mg 3 times daily after several weeks if the response is not adequate. .

The initial dose of sustained-release tablets is 150 mg daily; target dose is 150 mg twice daily; maximum dose is 200 mg twice daily.

The initial dose of extended-release tablets is 150 mg daily; target dose is 300 mg daily; maximum dose is 450 mg daily. Alternatively initiate at 174 mg daily and increase to 348 mg daily after 4 days and up to a maximum dose of 522 mg daily after 4 weeks. Extended release tablets are administered once daily.

When used for smoking cessation, bupropion (Zyban) usually is started as 150 mg once daily for three days, and then the dose is increased to 150 mg twice daily for 7 to 12 weeks if the patient tolerates the starting dose.

Smoking is discontinued two weeks after starting bupropion therapy.

The dose for seasonal affective disorder is 150 mg once daily. Wellbutrin SR is given as two daily doses. Wellbutrin XL is given as one dose daily, up to 300 mg daily using extended release tablets. Alternatively treatment may be started with 174 mg daily and increased to a target dose of 348 mg day. Start treatment in the autumn prior to onset of seasonal depressive symptoms, and continue through the winter season.

DRUG INTERACTIONS: Bupropion should be used cautiously in patients receiving drugs that reduce the threshold for seizures. Such drugs include prochlorperazine (Compazine), chlorpromazine (Thorazine}, and other antipsychotic medications of the phenothiazine class. Additionally, persons who are withdrawing from benzodiazepines (for example, diazepam [Valium], alprazolam [Xanax]) are at increased risk for seizures.

Medically Reviewed by a Doctor on 1/22/2014


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