bupivacaine (Marcaine; Sensorcaine) (cont.)

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SIDE EFFECTS: Side effects are related to higher doses, as well as unintentional injection into alternative sites. Absorption into the blood stream may lead to the following sied effects:

Other important side effects include:

Rare, but serious complications include decreased function of the nervous system, activation of the nervous system (resulting in seizures), paraplegia, nerve disorder, total block of spinal nerves, and respiratory arrest. Specific warnings exist about using the 0.75 % dose in obstetrical anesthesia as there have been reports of cardiac arrest.



PREPARATIONS: Intrathecal solution and injection solution with or without methylparaben and or preservatives: 0.25%, 0.5%, 0.75% in 2, 10, 30, 50 mL. Preservative free formulations should be used in caudal or epidural block.

STORAGE: Bupivacaine should be stored at room temperature, between 20 C to 25 C (68 F to 77 F).

DOSING: The initial dose for adults depends on the procedure, necessary depth of anesthesia, blood flow to the region, desired duration of anesthesia, and the condition of the patient. For example, in surgical procedures requiring a high degree of muscle relaxation and prolonged effects, 10-20 mL of 0.75% bupivacaine should be administered. Smaller procedures will require smaller doses.

DRUG INTERACTIONS: Therapy should be monitored when used with beta-blockers, such as atenolol (Tenormin), as they may increase the concentration of bupivacaine.

Medically Reviewed by a Doctor on 9/28/2015

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