bupivacaine (Marcaine; Sensorcaine)

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GENERIC NAME: bupivacaine

BRAND NAMES: Marcaine; Sensorcaine

DRUG CLASS AND MECHANISM: Bupivacaine is a local anesthetic that is similar to lidocaine and mepivacaine (amide type). Bupivacaine, like other local anesthetics reduces the flow of sodium in and out of nerves. This decreases the initiation and transfer of nerve signals in the area in which the drug is applied. This blockage leads first to a loss of sensation of pain, then temperature, touch, deep pressure, and muscle control. The concentration of the drug will determine how quickly it starts working. The FDA approved bupivacaine in October 1972.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Intrathecal solution and injection solution with or without methylparaben and or preservatives: 0.25%, 0.5%, 0.75% in 2, 10, 30, 50 mL. Preservative free formulations should be used in caudal or epidural block.

STORAGE: Bupivacaine should be stored at room temperature, between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Bupivacaine is prescribed for local or regional anesthesia (loss of sensation) or analgesia (decreased pain) for surgical, dental, diagnostic, and obstetrical procedures.

DOSING: The initial dose for adults depends on the procedure, necessary depth of anesthesia, blood flow to the region, desired duration of anesthesia, and the condition of the patient. For example, in surgical procedures requiring a high degree of muscle relaxation and prolonged effects, 10-20 mL of 0.75% bupivacaine should be administered. Smaller procedures will require smaller doses.

DRUG INTERACTIONS: Therapy should be monitored when used with beta-blockers, such as atenolol (Tenormin), as they may increase the concentration of bupivacaine.

Medically Reviewed by a Doctor on 6/27/2014



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