budesonide nasal inhaler-spray, Rhinocort (Discontinued brand), Rhinocort Aqua (cont.)

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DOSING: In adults and in children over the age of 6 years, the recommended starting dose of budesonide is 1 spray in each nostril once daily. The maximum dose for children older than 12 years of age and adults is 4 sprays per nostril once daily. The maximum dose for children younger than 12 years of age is 2 sprays per nostril once daily.

DRUG INTERACTIONS: Ketoconazole (Nizoral, Extina, Xolegel, Kuric), itraconazole (Sporanox), ritonavir (Norvir), atazanavir (Reyataz), clarithromycin (Biaxin, Biaxin XL), indinavir (Crixivan), and telithromycin increase the concentration in blood of budesonide by decreasing the elimination of budesonide from the body. This may lead to an increase in the side effects of budesonide.

PREGNANCY: When given orally to animals, glucocorticoid steroids similar to budesonide have been shown to cause fetal abnormalities. Studies of pregnant women using inhaled budesonide during early pregnancy do not show an increase in the rate of fetal abnormalities. Nevertheless, since these studies cannot completely exclude rare abnormalities, budesonide should be used during pregnancy only if it clearly is needed.

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