Is brexpiprazole safe to take if I'm pregnant or breastfeeding?

Unborn babies exposed to antipsychotics during the third trimester of pregnancy are at risk for extrapyramidal and withdrawal symptoms after birth. Symptoms reported included agitation, hypertonia, hypotonia, tremor, somnolence, depressed breathing, and feeding disorder. Currently there is no data on the use of brexpiprazole during pregnancy. Brexpiprazole should only be used during pregnancy if the potential benefit to the mother outweighs the potential for side effects in the unborn baby.

A pregnancy exposure registry has been established to monitor the use of atypical antipsychotics, including brexpiprazole, during pregnancy. All pregnant women treated with atypical antipsychotics are advised to enroll in this pregnancy registry and report any side effects.

Brexpiprazole is known to enter human milk but its effects on the breastfeeding infant or milk production is not yet known.

What else should I know about brexpiprazole?

What preparations of brexpiprazole are available?

Tablets: 0.25, 0.5, 1, 2, 3, and 4 mg

How should I keep brexpiprazole stored?

Brexpiprazole should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).

REFERENCE: FDA Prescribing Information

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