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The Cleveland Clinic

Breast Cancer:
Side Effects of Treatment: Lymphedema

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cellulitis, edema, lymph nodes, lymphoma
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Introduction to Lymphedema

The lymphatic system helps coordinate the immune system's function to protect the body from foreign substances and includes an extensive network of lymph vessels and lymph nodes. Here's how the lymphatic system works:

Excess fluid is collected from the space between tissues in the body and moves through the lymph vessels. The fluid (now called lymph) isn't pumped through the body like blood, but instead is "pushed" through the lymph system as the vessels are compressed by surrounding muscles.

Filters called lymph nodes remove certain harmful substances from the lymph fluid, such as bacteria and debris. The fluid from most tissues or organs is filtered through one or more lymph nodes before draining into the bloodstream.

What Is Lymphedema?

Lymphedema is an abnormal buildup of fluid that causes swelling, most often in the arms or legs. The condition develops when lymph vessels or lymph nodes are missing, impaired, damaged, or removed.

There are two types of lymphedema: primary and secondary. Primary lymphedema is rare and is caused by the absence of certain lymph vessels at birth, or abnormalities in the lymphatic vessels. Secondary lymphedema occurs as a result of a blockage or interruption that alters the flow of lymph through the lymphatic system and can develop from an infection, malignancy, surgery, scar tissue formation, trauma, deep vein thrombosis (blood clot in a vein), radiation, or other cancer treatment.



Next: Who is at risk for developing lymphedema? »

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Breast Cancer and Lymphedema

What are lymph nodes?

Lymph nodes are an important component of the body's immune system and help in fighting infections.

They are small, soft, round or oval structures that are found throughout the body and are connected to each other in chain-like (lymphatic chains) fashion by channels similar to blood vessels. Each individual lymph node is covered by a capsule made up of connective tissue.

Within the capsule, lymph nodes contain certain kinds of immune cells. These cells are mainly lymphocytes, which produce proteins that capture and fight viruses and other microbes, and macrophages, which destroy and remove the captured material.

Where are the lymph nodes located in the body?

Lymph nodes are located throughout the body. Some are directly under the skin while others are deep inside the body. Even the most superficial (close to the skin) lymph nodes are usually not visible or palpable (felt by touchi...

Read the Swollen Lymph Nodes article »










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