The following are health and medical definitions of terms that appear in the Breast Cancer article.
Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer).
Acquired: Anything that is not present at birth but develops some time later. In medicine, the word "acquired" implies "new" or "added." An acquired condition is "new" in the sense that it is not genetic (inherited) and "added" in the sense that was not present at birth. See the entire definition of Acquired
Adenoid cystic carcinoma: A type of cancer that most often develops in the salivary glands of the head and neck. It may arise in other sites such as the skin, lacrimal gland, trachea, breast, cervix and prostate. Adenoid cystic carcinoma (ACC) has a characteristic appearance under the microscope. Abnormal "nests" or cords of certain cells (epithelial cells) can be seen to surround or infiltrate ducts and glandular structures. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes (hyaline membranes). See the entire definition of Adenoid cystic carcinoma
Adjacent: Lying nearby. Related terms include superjacent, subjacent, and circumjacent. From ad-, near + the Latin jacere, to lie = to lie near.
Adjuvant: The Latin "adjuvans" means to help, particularly to reach a goal. See the entire definition of Adjuvant
Analysis: A psychology term for processes used to gain understanding of complex emotional or behavioral issues.
Anastrozole: An oral antiestrogen. Anastrozole inhibits the enzyme aromatase in the adrenal glands that produces the estrogens (estradiol and estrone) and thereby lowers their levels. Brand name: Arimidex. See the entire definition of Anastrozole
Anatomy: The study of form. Gross anatomy involves structures that can be seen with the naked eye. It is as opposed to microscopic anatomy (or histology) which involves structures seen under the microscope. Traditionally, both gross and microscopic anatomy have been studied in the first year of medical school in the U.S. The most celebrated textbook of anatomy in the English-speaking world is Gray's Anatomy, still a useful reference book. The word "anatomy" comes from the Greek ana- meaning up or through + tome meaning a cutting. Anatomy was once a "cutting up" because the structure of the body was originally learned through dissecting it, cutting it up. The abbreviation for anatomy is anat.
Angiogenesis: The process of developing new blood vessels. Angiogenesis is important in the normal development of the embryo and fetus. It also appears important to tumor formation. Certain proteins, including angiostatin and endostatin, secreted by tumors work (at least in mice) by interfering with the blood supply tumors need. Angiostatin is a piece of a larger and very common protein, plasminogen, that the body uses in blood clotting. Endostatin is a piece of a different protein, collagen 18, that is in all blood vessels.
Angiosarcoma: A type of cancer that begins in the lining of blood vessels. This type of tumor tends to be aggressive, recur locally, and spread widely. It can originate anywhere in the body but is well known to arise in skin, soft tissue, liver, breast, spleen, bone, lung and heart. Factors predisposing to angiosarcoma include chronic lymphedema (as from a radical mastectomy), radiotherapy, foreign materials (such as Dacron, shrapnel, steel, and plastic) in the body, and environmental agents (such arsenic solutions used to spray grapevines, the radiation-emitting contrast agent Thorotrast, and vinyl chloride in the plastic industry).
Antibody: An immunoglobulin, a specialized immune protein, produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production. See the entire definition of Antibody
Arimidex: Brand name for anastrozole, an oral antiestrogen. Arimidex inhibits the enzyme aromatase in the adrenal glands that produces the estrogens (estradiol and estrone) and thereby lowers their levels. See the entire definition of Arimidex
Aromasin: Brand name of exemestane, an oral antiestrogen. Aromasin inhibits the enzyme aromatase in the adrenal glands that produces the estrogens (estradiol and estrone) and thereby lowers their levels. See the entire definition of Aromasin
Aromatase: An enzyme involved in the production of estrogen that acts by catalyzing the conversion of testosterone (an androgen) to estradiol (an estrogen). Aromatase is located in estrogen-producing cells in the adrenal glands, ovaries, placenta, testicles, adipose (fat) tissue, and brain. See the entire definition of Aromatase
Aspiration: Removal of a sample of fluid and cells through a needle. Aspiration also refers to the accidental sucking in of food particles or fluids into the lungs.
Atypical: Not typical, not usual, not normal, abnormal. Atypical is often used to refer to the appearance of precancerous or cancerous cells.
Axillary: Pertaining to the cavity beneath the junction of the arm and the body, better known as the armpit. See the entire definition of Axillary
Baseline:1. Information gathered at the beginning of a study from which variations found in the study are measured. 2. A known value or quantity with which an unknown is compared when measured or assessed. 3. The initial time point in a clinical trial, just before a participant starts to receive the experimental treatment which is being tested. At this reference point, measurable values such as CD4 count are recorded. Safety and efficacy of a drug are often determined by monitoring changes from the baseline values.
Benign: Not cancer. Not malignant. A benign tumor does not invade surrounding tissue or spread to other parts of the body. A benign tumor may grow but it stays put (in the same place). See the entire definition of Benign
Bevacizumab: Generic name for a monoclonal antibody anticancer drug. See: Avastin.
Biopsy: The removal of a sample of tissue for purposes of diagnosis. (Many definitions of "biopsy" stipulate that the sample of tissue is removed for examination under a microscope. This may or may not be the case. The diagnosis may be achieved by other means such as by analysis of chromosomes or genes.) See the entire definition of Biopsy
Bone scan: A technique to create images of bones on a computer screen or on film. A small amount of radioactive material is injected and travels through the bloodstream. It collects in the bones, especially in abnormal areas of the bones, and is detected by special instrument called a scanner. The image of the bones is recorded on a special film for permanent viewing. See the entire definition of Bone scan
Brachytherapy: Radiation treatment given by placing radioactive material directly in or near the target, which is often a tumor. See the entire definition of Brachytherapy
Brain: That part of the central nervous system that is located within the cranium (skull). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."
Breast biopsy: A procedure in which a sample of a suspicious breast growth is removed and examined, usually for the presence of cancer. The sample is suctioned out through a needle or removed surgically. See the entire definition of Breast biopsy
Breast cancer:Breast cancer is diagnosed with self- and physician-examination of the breasts, mammography, ultrasound testing, and biopsy. There are many types of breast cancer that differ in their capability of spreading to other body tissues (metastasis). Treatment of breast cancer depends on the type and location of the breast cancer, as well as the age and health of the patient. The American Cancer Society recommends that a woman should have a baseline mammogram between the ages of 35 and 40 years. Between 40 and 50 years of age mammograms are recommended every other year. After age 50 years, yearly mammograms are recommended.
Breast lump: A localized swelling, knot, bump, bulge or protuberance in the breast. Breast lumps may appear in both sexes at all ages. In women, the fear is usually of breast cancer but many breast lumps turn out, fortunately, to be due to benign conditions that can be successfully treated such as infection, trauma, fibroadenoma, cyst, or fibrocystic condition of the breast. However, no breast lump should be dismissed as benign until it has been checked by a physician.
Breastfeeding: Feeding a child human breast milk. According to the American Academy of Pediatrics, human breast milk is preferred for all infants. This includes even premature and sick babies, with rare exceptions. It is the food least likely to cause allergic reactions; it is inexpensive; it is readily available at any hour of the day or night; babies accept the taste readily; and the antibodies in breast milk can help a baby resist infections. See the entire definition of Breastfeeding
Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread). See the entire definition of Cancer
Cancer detection: Methods used to find cancer in persons who may or may not have symptoms. Symptoms of cancer are abnormal sensations or conditions that persons can notice that are a result of the cancer. It is important to your doctor for regular checkups and not wait for problems to occur. But you should also know that the following symptoms may be associated with cancer: changes in bowel or bladder habits, a sore that does not heal, unusual bleeding or discharge, thickening or lump in the breast or any other part of the body, indigestion or difficulty swallowing, obvious change in a wart or mole, or nagging cough or hoarseness. These symptoms are not always a sign of cancer. They can also be caused by less serious conditions. Only a doctor can make a diagnosis. It is important to see a doctor if you have any of these symptoms. Don't wait to feel pain. Early cancer often does not cause pain.
Cancer symptoms: Abnormal sensations or conditions that persons can notice that are a result of a cancer. It is important to see your doctor for regular checkups and not wait for problems to occur. But you should also know that the following symptoms may be associated with cancer: changes in bowel or bladder habits, a sore that does not heal, unusual bleeding or discharge, thickening or lump in the breast or any other part of the body, indigestion or difficulty swallowing, obvious change in a wart or mole, or nagging cough or hoarseness. These symptoms are not always a sign of cancer. They can also be caused by less serious conditions. Only a doctor can make a diagnosis. It is important to see a doctor if you have any of these symptoms. Don't wait to feel pain. Early cancer often does not cause pain.
Carcinoma:Cancer that begins in the skin or in tissues that line or cover body organs. For example, carcinoma can arise in the breast, colon, liver, lung, prostate, and stomach.
Carcinoma in situ: Cancer that involves only the place in which it began and that has not spread. Carcinoma in situ is an early-stage tumor. See the entire definition of Carcinoma in situ
Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane. See the entire definition of Cell
Chemoprevention: The use of natural or laboratory-made substances to prevent a disease such as cancer. The regular use of aspirin is known to reduce the risk of the polyps from which colorectal cancer arises. This is an instance of chemoprevention. See the entire definition of Chemoprevention
Chemotherapy:1. In the original sense, a chemical that binds to and specifically kills microbes or tumor cells. The term chemotherapy was coined in this regard by Paul Ehrlich (1854-1915). 2. In oncology, drug therapy for cancer. Also called "chemo" for short. See the entire definition of Chemotherapy
Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum. See the entire definition of Chest
Chest X-ray: Commonly used to detect abnormalities in the lungs, but can also detect abnormalities in the heart, aorta, and the bones of the thoracic area. Metallic objects, such as jewelry are removed from the chest and neck areas for a chest x-ray to avoid interference with x-ray penetration and improve accuracy of the interpretation.
Clavicle: The bone extending from the breastbone (sternum) at the base of the front of the neck to the shoulder.
Clinical trials: Trials to evaluate the effectiveness and safety of medications or medical devices by monitoring their effects on large groups of people. See the entire definition of Clinical trials
Cluster: In epidemiology, an aggregation of cases of a disease or another health-related condition, such as a cancer or birth defect, closely grouped in time and place. The number of cases in the cluster may or may not exceed the expected number. This is determined by cluster analysis, a set of statistical methods used to analyze clusters.
Computerized tomography: Pictures of structures within the body created by a computer that takes the data from multiple X-ray images and turns them in pictures. See the entire definition of Computerized tomography
CT scan: Computerized tomography scan. Pictures of structures within the body created by a computer that takes the data from multiple X-ray images and turns them into pictures on a screen. CT stands for computerized tomography. See the entire definition of CT scan
Cure:1. To heal, to make well, to restore to good health. Cures are easy to claim and, all too often, difficult to confirm. 2. A time without recurrence of a disease so that the risk of recurrence is small, as in the 5-year cure rate for malignant melanoma. 3. Particularly in the past, a course of treatment. For example, take a cure at a spa. See the entire definition of Cure
DCIS: Ductal carcinoma in situ. A precancerous condition characterized by the clonal proliferation of malignant-looking cells in the lining of a breast duct without evidence of spread outside the duct to other tissues in the breast or outside the breast. DCIS is clearly the precursor (forerunner) of invasive breast cancer. This is evident from the sharing of clonal chromosome changes by DCIS and adjacent invasive cancers. In other words, invasive breast cancer evolves from DCIS. Also called intraductal carcinoma. See the entire definition of DCIS
Diagnosis:1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV. See the entire definition of Diagnosis
Diethylstilbestrol: The earliest synthetic (man-made) form of the hormone estrogen. See the entire definition of Diethylstilbestrol
Discharge:1.The flow of fluid from part of the body, such as from the nose or vagina. 2. The passing of an action potential, such as through a nerve or muscle fiber. 3. The release of a patient from a course of care. The doctor may then dictate a discharge summary.
Dissection: The process of cutting apart or separating tissue as, for example, in the study of anatomy or in the course of a surgical procedure.
DNA: Deoxyribonucleic acid. One of two types of molecules that encode genetic information. (The other is RNA. In humans DNA is the genetic material; RNA is transcribed from it. In some other organisms, RNA is the genetic material and, in reverse fashion, the DNA is transcribed from it.) See the entire definition of DNA
Duct: A passage or a tube with well-defined walls suitable for the conveyance of air or liquids, as the bile duct and the pancreatic duct. See the entire definition of Duct
Estrogen: Estrogen is a female hormone produced by the ovaries. Estrogen deficiency can lead to osteoporosis. See the entire definition of Estrogen
Estrogens: Female hormones produced by the ovaries. Estrogen deficiency can lead to osteoporosis. See the entire definition of Estrogens
Exemestane: An oral antiestrogen. Exemestane inhibits the enzyme aromatase in the adrenal glands that produces the estrogens (estradiol and estrone) and thereby lowers their levels. Brand name: Aromasin. See the entire definition of Exemestane
Family history: The family structure and relationships within the family, including information about diseases in family members. See the entire definition of Family history
Father: (1) The male parent. (2) One who originates. For example, "Wilhelm Roentgen is considered the father of radiology." (3) To produce offspring as a male. (4) To provide paternal protection and guidance to children.
Femara: Brand name for letrozole, an oral antiestrogen. Femara inhibits the enzyme aromatase in the adrenal glands that produces the estrogens (estradiol and estrone) and thereby lowers their levels. See the entire definition of Femara
Gene: The basic biological unit of heredity. A segment of deoxyribonucleic acid (DNA) needed to contribute to a function. See the entire definition of Gene
Gene testing: Testing a sample of blood (or another fluid or tissue) for evidence of a gene. The evidence can be biochemical, chromosomal, or genetic. The aim is to learn whether a gene for a disease is present or absent.
Genes: The basic biological units of heredity. Segments of deoxyribonucleic acid (DNA) needed to contribute to a function. See the entire definition of Genes
Genetic: Having to do with genes and genetic information.
Genetic counseling: An educational counseling process for individuals and families who have a genetic disease or who are at risk for such a disease. Genetic counseling is designed to provide patients and their families with information about their condition and help them make informed decisions. See the entire definition of Genetic counseling
Genetic counselor: A health professional with a specialized graduate degree and experience in the areas of medical genetics and counseling. See the entire definition of Genetic counselor
Genetic testing: Tests done for clinical genetic purposes. Genetic tests may be done for diverse purposes pertaining to clinical genetics, including the diagnosis of genetic disease in children and adults; the identification of future disease risks; the prediction of drug responses; and the detection of risks of disease to future children.
Gland:1. A group of cells that secrete a substance for use in the body. For example, the thyroid gland. 2. A group of cells that removes materials from the circulation. For example, a lymph gland.
HER2: Abbreviation for human epidermal growth factor receptor 2. See the entire definition of HER2
Hormone: A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. See the entire definition of Hormone
Hormone therapy: A form of treatment that takes advantage of the fact that certain cancers depend on hormones to grow. Hormone therapy may include giving hormones to the patient or decreasing the level of hormones in the body.
Hyperplasia: A condition in which there is an increase in the number of normal cells in a tissue or organ.
Immune: Protected against infection. The Latin immunis means free, exempt.
Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders. See the entire definition of Immune system
In situ: In the normal location. An "in situ" tumor is one that is confined to its site of origin and has not invaded neighboring tissue or gone elsewhere in the body. See the entire definition of In situ
Incidence: The frequency with which something, such as a disease, appears in a particular population or area. In disease epidemiology, the incidence is the number of newly diagnosed cases during a specific time period. The incidence is distinct from the prevalence which refers to the number of cases alive on a certain date.
Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated.
Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person. See the entire definition of Infection
Joint: A joint is the area where two bones are attached for the purpose of motion of body parts. A joint is usually formed of fibrous connective tissue and cartilage. An articulation or an arthrosis is the same as a joint. See the entire definition of Joint
Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."
Letrozole: An oral antiestrogen. Letrozole inhibits the enzyme aromatase in the adrenal glands that produces the estrogens (estradiol and estrone) and thereby lowers their levels. The brand name of letrozole is Femara. See the entire definition of Letrozole
Lifetime risk: The risk of developing a disease during ones lifetime or dying of the disease. The estimated lifetime risk of developing diabetes for individuals born in 2000 in the US is 32.8% for males and 38.5% for females. Women who inherit mutations of the BRCA1 or BRCA2 gene are at an 82% lifetime risk of developing breast cancer. The lifetime risk of dying from prostate cancer is 3.4% for American men. However, the lifetime risk of death for the entire population is 100%.
Lumpectomy: The surgical removal of a small tumor (a lump) which may or may not be benign (or malignant). Lumpectomy has come to refer specially to the removal of a lump from the breast. See the entire definition of Lumpectomy
Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.
Lymph: An almost colorless fluid that travels through vessels called lymphatics in the lymphatic system and carries cells that help fight infection and disease.
Lymph node: Also sometimes referred to as lymph glands, lymph nodes are small rounded or bean-shaped masses of lymphatic tissue surrounded by a capsule of connective tissue. Lymph nodes are located in many places in the lymphatic system throughout the body. Lymph nodes filter the lymphatic fluid and store special cells that can trap cancer cells or bacteria that are traveling through the body in the lymph fluid. The lymph nodes are critical for the body's immune response and are principal sites where many immune reactions are initiated. During a physical examination, doctors often look for swollen lymph nodes in areas where lymph nodes are abundant, including the neck, around the collarbone, the armpit (axilla), and the groin. See the entire definition of Lymph node
Lymphatic:1. One of the lymphatics, vessel that convey the lymph fluid. 2. Pertaining to the lymph, lymphoid tissue, or lymphocytes. 3. Lacking energy. Sluggish. From the Latin lympha (water or water goddess), from the Greek nymphe (nymph).
Lymphedema: A common chronic, debilitating condition in which excess fluid called lymph collects in tissues and causes swelling (edema) in them. See the entire definition of Lymphedema
Malignancy: A tumor that is malignant, that is cancerous, that can invade and destroy nearby tissue, and that may spread (metastasize) to other parts of the body.
Malignant:1. Tending to be severe and become progressively worse, as in malignant hypertension. 2. In regard to a tumor, having the properties of a malignancy that can invade and destroy nearby tissue and that may spread (metastasize) to other parts of the body. See the entire definition of Malignant
Mammogram: An X-ray of the breast with the breast in a device that compresses and flattens it. There are two basic mammogram tests -- screening mammograms and diagnostic mammograms. See the entire definition of Mammogram
Mastectomy: A general term for removal of the breast, usually to remove cancerous tissue. The operation can be done in a hospital or in an outpatient clinic, depending on how extensive it needs to be. It takes from two to three hours, with three to five weeks for full recovery. Drainage shunts are left in the surgical incision for a few days after the operation; these are removed in three to five days if the area is healing normally. After the mastectomy, reconstructive surgery may be performed to restore a more normal appearance. Many patients choose to avoid reconstructive surgery, and wear special undergarments instead. In cases of non- metastatic breast cancer, a lumpectomy, radiation, chemotherapy, or a combination of these treatments may prove a viable alternative to mastectomy. If a lumpectomy is chosen, the surgeon may remove some lymph node tissue from under the arms to make sure cancer has not spread. See the entire definition of Mastectomy
Menopause: The time in a woman's life when menstrual periods permanently stop; it is also called the "change of life." Menopause is the opposite of the menarche. See the entire definition of Menopause
Menstrual cycle: The monthly cycle of changes in the ovaries and the lining of the uterus (endometrium), starting with the preparation of an egg for fertilization. When the follicle of the prepared egg in the ovary breaks, it is released for fertilization and ovulation occurs. Unless pregnancy occurs, the cycle ends with the shedding of part of the endometrium, which is menstruation. Although it is actually the end of the physical cycle, the first day of menstrual bleeding is designated as "day 1" of the menstrual cycle in medical parlance.
Menstruation: The periodic blood that flows as a discharge from the uterus. Also called menorrhea, the time during which menstruation occurs is referred to as menses. The menses occurs at approximately 4 week intervals to compose the menstrual cycle.
Metastasis:1. The process by which cancer spreads from the place at which it first arose as a primary tumor to distant locations in the body. 2. The cancer resulting from the spread of the primary tumor. For example, someone with melanoma may have a metastasis in their brain. And a person with colon cancer may, fortunately, show no metastases. See the entire definition of Metastasis
Metastasize: The spread from one part of the body to another. When cancer cells metastasize and cause secondary tumors, the cells in the metastatic tumor are like those in the original cancer.
Microscope: An optical instrument that augments the power of the eye to see small objects. The name microscope was coined by Johannes Faber (1574-1629) who in 1628 borrowed from the Greek to combined micro-, small with skopein, to view. Although the first microscopes were simple microscopes, most (if not all) optical microscopes today are compound microscopes.
Microscopic: So small it cannot be seen without the aid of microscope. As opposed to macroscopic (large enough to be seen with naked eye). A tiny tumor is microscopic while a big tumor is macroscopic.
Monoclonal: Pertaining to a single clone of cells, a single cell and the progeny of that cell. As opposed to polyclonal. See the entire definition of Monoclonal
Monoclonal antibody: An antibody produced by a single clone of cells (specifically, a single clone of hybridoma cells) and therefore a single pure homogeneous type of antibody. Monoclonal antibodies can be made in large amounts in the laboratory and are a cornerstone of immunology. The term "monoclonal" pertains to a single clone of cells, a single cell and the progeny of that cell. See the entire definition of Monoclonal antibody
Mouth:1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.
Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."
Mutation: A permanent change, a structural alteration, in the DNA or RNA. In humans and many other organisms, mutations occur in DNA. However, in retroviruses like HIV, mutations occur in RNA which is the genetic material of retroviruses. See the entire definition of Mutation
Node: Literally a knot, a node is a collection of tissue. For example a lymph node, is a collection of lymphoid tissue. A nodule is a small node, a little collection of tissue.
Obese: Well above ones normal weight. A person has traditionally been considered to be obese if they are more than 20 percent over their ideal weight. That ideal weight must take into account the person's height, age, sex, and build. See the entire definition of Obese
Objective: In a microscope, the objective (also called the objective lens) is the lens nearest to the object being examined whereas the lens closest to the eye is termed the ocular (the eyepiece). See the entire definition of Objective
Oncogene:1. A gene that played a normal role in the cell as a proto-oncogene and that has been altered by mutation and now may contribute to the growth of a tumor. See the entire definition of Oncogene
Ovarian: Of or pertaining to the ovary.
Ovarian cancer: Cancer of the ovary, the egg sac of females. The anatomic location of the ovaries:
Ovary: The female gonad, the ovary is one of a pair of reproductive glands in women. They are located in the pelvis, one on each side of the uterus. Each ovary is about the size and shape of an almond. The ovaries produce eggs (ova) and female hormones. During each monthly menstrual cycle, an egg is released from one ovary. The egg travels from the ovary through a fallopian tube to the uterus. The ovaries are the main source of female hormones, which control the development of female body characteristics, such as the breasts, body shape, and body hair. They also regulate the menstrual cycle and pregnancy.
Overweight: The term "overweight" is used in two different ways. In one sense it is a way of saying imprecisely that someone is heavy. The other sense of "overweight" is more precise and designates a state between normal weight and obesity. See the entire definition of Overweight
Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors. See the entire definition of Pain
Pathologic:1. Indicative of or caused by disease, as in a pathologic fracture, pathologic tissue, or pathologic process. 2. Pertaining to pathology, the branch of medicine that studies disease and especially the essential nature of disease.
Pathologist: A doctor who identifies diseases by studying cells and tissues under a microscope.
Pathology: The study of disease. Pathology has been defined as "that branch of medicine which treats of the essential nature of disease." The word "pathology" comes from the Greek words "pathos" meaning "disease" and "logos" meaning "a treatise" = a treatise of disease. The word "pathology" is sometimes misused to mean disease as, for example, "he didn't find any pathology" (meaning he found no evidence of disease). A medical doctor that specializes in pathology is called a pathologist. Pathologists are experts at interpreting microscopic views of body tissues.
Physiologic: Something that is normal, neither due to anything pathologic nor significant in terms of causing illness.
Positron emission tomography: PET. A highly specialized imaging technique that uses short-lived radioactive substances to produce three-dimensional colored images of those substances functioning within the body. These images are called PET scans and the technique is termed PET scanning. See the entire definition of Positron emission tomography
Postmenopausal: After the menopause. Postmenopausal is defined formally as the time after which a woman has experienced twelve (12) consecutive months of amenorrhea (lack of menstruation) without a period. See the entire definition of Postmenopausal
Primary tumor: A tumor that is at the original site where it first arose. For example, a primary brain tumor is one that arose in the brain as opposed to one that arose elsewhere and metastasized (spread) to the brain. The original tumor is sometimes called "the primary."
Progesterone: A female hormone and the principal progestational hormone that is made mainly by the corpus luteum in the ovary and by the placenta. Progesterone prepares the lining (endometrium) of the uterus (the womb) to receive and sustain the fertilized egg and so permits pregnancy. Similarly refers to synthetic versions of the hormone. Also known as progestational hormone.
Prognosis:1. The expected course of a disease. 2. The patient's chance of recovery. The prognosis predicts the outcome of a disease and therefore the future for the patient. His prognosis is grim, for example, while hers is good. See the entire definition of Prognosis
Prostate: A gland within the male reproductive system that is located just below the bladder. Chestnut shaped, the prostate surrounds the beginning of the urethra, the canal that empties the bladder. See the entire definition of Prostate
Prostate cancer: An uncontrolled (malignant) growth of cells in the prostate gland which is located at the base of the urinary bladder and is responsible for helping control urination as well as forming part of the semen. Prostate cancer is the second leading cause of death of males in the U.S.
Prosthesis: An artificial substitute or replacement of a part of the body such as a tooth, eye, a facial bone, the palate, a hip, a knee or another joint, the leg, an arm, etc. A prosthesis is designed for functional or cosmetic reasons or both. See the entire definition of Prosthesis
Protein: A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein. See the entire definition of Protein
Proteins: Large molecules composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein. See the entire definition of Proteins
Radiation:1. Rays of energy. Gamma rays and X-rays are two of the types of energy waves often used in medicine. 2. The use of energy waves to diagnose or treat disease. See also: Irradiation.
Radiation therapy: The use of high-energy rays to damage cancer cells, stopping them from growing and dividing. Like surgery, radiation therapy is a local treatment that affects cancer cells only in the treated area. See the entire definition of Radiation therapy
Radioactive: Emitting energy waves due to decaying atomic nuclei. Radioactive substances are used in medicine as tracers for diagnosis, and in treatment to kill cancerous cells.
Radiologist: A physician specialized in radiology, the branch of medicine that uses ionizing and nonionizing radiation for the diagnosis and treatment of disease. See the entire definition of Radiologist
Receptor:1. In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are many receptors. There is a receptor for (insulin; there is a receptor for low-density lipoproteins (LDL); etc. To take an example, the receptor for substance P, a molecule that acts as a messenger for the sensation of pain, is a unique harbor on the cell surface where substance P docks. Without this receptor, substance P cannot dock and cannot deliver its message of pain. Variant forms of nuclear hormone receptors mediate processes such as cholesterolmetabolism and fatty acid production. Some hormone receptors are implicated in diseases such as diabetes and certain types of cancer. A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions. 2. In neurology, a terminal of a sensorynerve that receives and responds to stimuli.
Recur: To occur again. To return. Any symptom (such as fatigue), any sign (such as a heart murmur), or any disease can recur.
Recurrence: The return of a sign, symptom or disease after a remission. The reappearance of cancer cells at the same site or in another location is, unfortunately, a familiar form of recurrence. See the entire definition of Recurrence
Recurrent: Back again. A recurrent fever is a fever that has returned after an intermission: a recrudescent fever.
Resection: Surgical removal of part of an organ.
Risk of recurrence: In medical genetics, the chance that a genetic (inherited) disease present in a family will recur in that family. The concept in general medicine means the chance that an illness we come back again.
Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device. See the entire definition of Scan
Screening mammogram: A mammogram (an X-ray of the breast) in women who have no signs of breast cancer. It usually involves two X-rays of each breast. The aim of a screening mammogram is to detect a tumor that cannot be felt. See the entire definition of Screening mammogram
Sentinel lymph node: The first lymph node ("gland") to receive lymphatic drainage from a tumor. See the entire definition of Sentinel lymph node
Sentinel lymph node biopsy: Examination of the first lymph node ("gland") that receives lymphatic drainage from a tumor to determine whether that node does or does not have tumor cells within it. See the entire definition of Sentinel lymph node biopsy
Sporadic: Occurring upon occasion or in a scattered, isolated or seemingly random way. See the entire definition of Sporadic
Stage: As regards cancer, the extent of a cancer, especially whether the disease has spread from the original site to other parts of the body. See also: Staging.
Staging: In regard to cancer, the process of doing examinations and tests to learn the extent of the cancer, especially whether it has metastasized (spread) from its original site to other parts of the body.
Surgeon: A physician who treats disease, injury, or deformity by operative or manual methods. A medical doctor specialized in the removal of organs, masses and tumors and in doing other procedures using a knife (scalpel). The definition of a "surgeon" has begun to blur in recent years as surgeons have begun to minimize the cutting, employ new technologies that are "minimally invasive," use scopes, etc. See the entire definition of Surgeon
Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office. See the entire definition of Surgery
Tomography: The process for generating a tomogram, a two-dimensional image of a slice or section through a three-dimensional object. Tomography achieves this remarkable result by simply moving an x-ray source in one direction as the x-ray film is moved in the opposite direction during the exposure to sharpen structures in the focal plane, while structures in other planes appear blurred. The tomogram is the picture; the tomograph is the apparatus; and tomography is the process. See the entire definition of Tomography
Trigger: Something that either sets off a disease in people who are genetically predisposed to developing the disease, or that causes a certain symptom to occur in a person who has a disease. For example, sunlight can trigger rashes in people with lupus.
Tubes: The "tubes" are medically known as the Fallopian tubes. There are two Fallopian tubes, one on each side, which transport the egg from the ovary to the uterus (the womb). The Fallopian tubes have small hair-like projections called cilia on the cells of the lining. See the entire definition of Tubes
Tumor: An abnormal mass of tissue. Tumors are a classic sign of inflammation, and can be benign or malignant (cancerous). There are dozens of different types of tumors. Their names usually reflect the kind of tissue they arise in, and may also tell you something about their shape or how they grow. For example, a medulloblastoma is a tumor that arises from embryonic cells (a blastoma) in the inner part of the brain (the medulla). Diagnosis depends on the type and location of the tumor. Tumor marker tests and imaging may be used; some tumors can be seen (for example, tumors on the exterior of the skin) or felt (palpated with the hands). See the entire definition of Tumor
Ultrasound: High-frequency sound waves. Ultrasound waves can be bounced off of tissues using special devices. The echoes are then converted into a picture called a sonogram. Ultrasound imaging, referred to as ultrasonography, allows physicians and patients to get an inside view of soft tissues and body cavities, without using invasive techniques. Ultrasound is often used to examine a fetus during pregnancy. There is no convincing evidence for any danger from ultrasound during pregnancy.
Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system. See the entire definition of Vascular
Vessel: A tube in the body that carries fluids: blood vessels or lymph vessels.
X-ray:1. High-energy radiation with waves shorter than those of visible light. X-rays possess the properties of penetrating most substances (to varying extents), of acting on a photographic film or plate (permitting radiography), and of causing a fluorescent screen to give off light (permitting fluoroscopy). In low doses X-rays are used for making images that help to diagnose disease, and in high doses to treat cancer. Formerly called a Roentgen ray. 2. An image obtained by means of X-rays.
Lymph nodes help the body's immune system fight infections. Causes of swollen lymph nodes (glands) may include infection (viral, bacterial, fungal, parasites). Symptoms of swollen lymph nodes vary greatly. They can sometimes be tender, painful or disfiguring. The treatment of swollen lymph nodes depends upon the cause.
Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous
system. When only the skin is involved, the condition is called discoid lupus.
When internal organs are involved, the condition is called systemic lupus
erythematosus (SLE).
Fibrocystic breast condition (sometimes called fibrocystic breast disease) is characterized by lumpiness and usually discomfort in one or both breasts. The condition is very common and benign (not malignant). Fibrocystic breast condition is the most common cause of "lumpy breasts" in women. A common symptom of fibrocystic breast condition is breast pain or discomfort. There are two types of fibrocystic breast condition, cysts and fibrosis, and Hyperplasia and atypical hyperplasia of breast cells.
Pleurisy, an inflammation of the lining around the lungs, is associated with sharp chest pain upon breathing in. Cough, chest tenderness, and shortness of breath are other symptoms associated with pleurisy. Pleurisy pain can be managed with pain medication and by external splinting of the chest wall.
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Pleural effusion is an excess fluid between the two membranes that envelop the lungs. There are two classifications of causes of pleural effusion; transudate and exudate. The treatment of pleural effusion depends on the cause.
Breast lumps in women can have a variety of causes such as breast inflammation, infection, injuries, cancer, and non-cancerous growths. Breast lumps in women are diagnosed with physical exam, mammogram, ultrasound, MRI, and biopsy. Treatment of breast lumps in women depend on the cause.
The breast generally refers to the chest, however, more specifically, to the mammary gland. The mammary gland is a milk producing gland comprised largely of fat. Within the mammary gland is a complex network of branching ducts. The ducts exit from sac-like structures called lobules, which can produce milk in females. The darkened area around the nipple is called the areola. Common medical concerns in regard to the breast include breast lumps, breast cysts, breast cancer, and breast infections.
Male breast cancer accounts for 1% of all breast cancers, and most cases are found in men between the ages of 60 and 70. A man's risk of developing breast cancer is one in 1,000. Signs and symptoms include a firm mass located below the nipple and skin changes around the nipple, including puckering, redness or scaling, retraction and ulceration of the nipple. Treatment depends upon staging and the health of the patient.
Phlebitis is the inflammation of a vein. Thrombophlebitis is when a blood clot causes the inflammation. Phlebitis can be superficial or deeper in the veins. A blood clot deep in a vein is deep vein thrombosis (DVT). Some of the common causes of phlebitis include prolonged inactivity, varicose veins, trauma to a vein, underlying cancers, clotting disorders, etc. Symptoms of phlebitis may be mild (pain, tenderness, redness, or bulging of a vein. Treatment of phlebitis depends on the cause.
Hypercalcemia is a condition in which calcium levels in the blood are elevated. Hypercalcemia is associated with other conditions such as hyperparathyroidism, lung cancer, breast cancer, kidney failure, and elevated levels of vitamin D. Symptoms of hypercalcemia include constipation, nausea, abdominal pain, kidney stones, to name a few. Treatment depends on the cause of hypercalcemia.
Lymphedema is a condition in which one or more extremities become swollen as the result of an impaired flow of the lymphatic system. There are two types of lymphedema; primary, secondary. Filariasis is the most common cause of lymphedema worldwide; however, in the U.S. breast cancer surgery is the most common cause. Symptoms include swelling of one or more limbs, thickening, cracked, and secondary bacterial or fungal infections of the skin. There is no cure for lymphedema.
Enjoying a satisfying sex life as we age is important to both physical and mental health. As we age, diseases and conditions may pose challenges in our sexual health, and sexual experiences. Learn how to manage your conditions and still have a gratifying sex life as you age.
Inflammatory breast cancer is an accelerated form of breast cancer that is not usually detected by mammogram or ultrasound. Symptoms of inflammatory breast cancer include pain in the breast, skin change in the breast area, bruise on the breast,sudden swelling of the breast, nipple retraction or discharge, and swelling of the lymph nodes.
Lymphedema is a common chronic, debilitating condition in which excess fluid called lymph collects in tissues and causes swelling in them. It is common after a mastectomy, lumpectomy or breast cancer surgery and radiation therapy.
Women's health is an important topic area to guide a woman through the stages of her life, as well as knowing the conditions and diseases that may occur. Educating yourself so that the transitions into different phases of life is key to a healthy, happy, and productive life.
Lifestyle changes, a healthy antioxidant-rich diet, exercise, and weight reduction can help reduce a woman's risk of developing breast cancer. It's important to be aware of how risk factors such as family history, lifestyle factors, breast conditions, radiation therapy, and hormonal factors may influence your chances of developing breast cancer. Mammography and breast self-examinations are crucial steps in breast cancer prevention.
Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests
are commonly available through your general doctor. Some specialized tests may be available elsewhere.
As breast cancer is the most diagnosed non-skin cancer in American women, it is important to know your breast cancer risk. Risk factors include age, age at menarche, age at first live birth, history of breast abnormalities, breast biopsies, race, and history or breast cancer among first-degree relatives.
The breast generally refers to the front of the chest
and medically
specifically to the mammary gland.
(The word "mammary" comes from "mamma," the Greek and Latin word
for the breast, which derives from the cry "mama" uttered by infants
and young children, sometimes meaning "I want to feed at the
breast.")
How is the mammary gland designed?
The mammary gland is a milk-producing structure that is composed
largely of fat cells (cells capable of storing fat). The fat deposits
are laid down in the breast under the influence of the female hormone estrogen. Just as
the surge of estrogens at adolescence encourages this process,
androgens, such as testosterone, discourage it.
Within the mammary gland there is a complex network of
branching ducts (tubes or channels). These ducts exit from sac-like
structures called lobules.
The lobules in the breast are the glands that can produce mil...
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