Breast
Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel,
Jr., MD, FACP, FACR
Families with Breast Cancer
Medical Author: Carolyn Janet Crandall, MD, FACP
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Ms. G. is a 40-year-old woman with two small
children. Like most women, she is concerned about her chances of developing
breast cancer. She asks her doctor about her risks.
Although breast cancer is a worry for most women, Ms. G. is especially worried because of a
family history of breast cancer. Her mother and sister had breast cancers that were diagnosed
at young ages.
A woman with a family history of breast cancer
has a lot of concerns. Among other things, she is thinking of her job, children,
and husband, as well as how her medical insurance and health team will be able
to serve her needs in the future should a crisis arise.
What are the facts about families that have multiple members with breast cancer?
Inherited breast cancer disorders account for a
small minority of breast cancers overall. Genes are the "messages" in
each cell of the body that determine the ultimate design of our bodies.
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What is the breast?
The breast generally refers to the front of the chest
and medically
specifically to the mammary gland.
(The word "mammary" comes from "mamma," the Greek and Latin word
for the breast, which derives from the cry "mama" uttered by infants
and young children, sometimes meaning "I want to feed at the
breast.")
How is the mammary gland designed?
The mammary gland is a milk-producing structure that is composed
largely of fat cells (cells capable of storing fat). The fat deposits
are laid down in the breast under the influence of the female hormone estrogen. Just as
the surge of estrogens at adolescence encourages this process,
androgens, such as testosterone, discourage it.
Within the mammary gland there is a complex network of
branching ducts (tubes or channels). These ducts exit from sac-like
structures called lobules.
The lobules in the breast are the glands that can produce milk in
females when they receive the appropriate hormonal stimulation.
The breast ducts transport milk from the lobules out to the
nipple. The ducts exit from the breast at the nipple.

Picture of the anatomy of the breast
How are human breasts different from those
of other primates?
Human breasts function somewhat differently than those
of other primates. In other primates, the breasts grow only when the female is
producing milk (lactating). When the non-human primate female has weaned her
young, her breasts flatten back down. In humans, the breasts develop at
adolescence usually well before any pregnancy has occurred and the breasts stay
enlarged throughout the remainder of life.
Next: What happens to the breasts in pregnancy? »
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