Botulism Glossary of Terms

Abdominal: Relating to the abdomen, the belly , that part of the body that contains all of the structures between the chest and the pelvis . The abdomen is separated anatomically from the chest by the diaphragm , the powerful muscle spanning the body cavity below the lungs .
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Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer ).
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Achalasia : A disease of the esophagus caused by the abnormal function of nerves and muscles of the esophagus that makes swallowing difficult. There may sometimes be chest pain. Regurgitation of undigested food can occur, as can coughing or breathing problems due to entry of food into the lungs. The underlying problems are weakness of the lower portion of the esophagus and failure of the lower esophageal sphincter to open and allow passage of food. Achalasia may occur at any age but is predominantly a disease of young adults. Diagnosis is made by an X-ray, endoscopy , or esophageal manometry (to measure the pressure in the esophagus). Treatment includes medication, dilation (stretching) to widen the lower part of the esophagus, and surgery to open the lower esophagus. A fairly recent approach involves injecting medicines into the lower esophagus to relax the sphincter.
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Acquired: Anything that is not present at birth but develops some time later. In medicine, the word "acquired" implies "new" or "added." An acquired condition is "new" in the sense that it is not genetic (inherited) and "added" in the sense that was not present at birth.
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Aluminum: A naturally occurring element that makes up about 8% of the surface of the earth and is always found combined with other elements such as oxygen, silicon, and fluorine. Aluminum is is the most common metallic element in the earth's crust but has no clear biologic role. Everyone is exposed to low levels of aluminum from food, air, and water. Exposure to high levels of aluminum may result in respiratory problems (aluminosis). Inhalation of bauxite (aluminum ore) fumes may cause pulmonary fibrosis . Aluminum in the bloodstream may lead to neurological symptoms and may be fatal.
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Antitoxin: An antibody capable of destroying microorganisms including viruses and bacteria.
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Arms: An appendage in anatomy and in clinical trials. See: Arm.

Bacteria: Single-celled microorganisms which can exist either as independent (free-living) organisms or as parasites (dependent upon another organism for life).
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Bacterial: Of or pertaining to bacteria. For example, a bacterial lung infection.

Bacterium: The singular of bacteria.

Blepharospasm: Involuntary forcible closure of the eyelids. The first symptom may be uncontrollable blinking. Only one eye may be affected initially, but eventually both eyes are usually involved. The spasms may leave the eyelids completely closed causing functional blindness even though the eyes and vision are normal. Blepharospasm is a form of focal dystonia.

Blood: The familiar red fluid in the body that contains white and red blood cells, platelets, proteins, and other elements. The blood is transported throughout the body by the circulatory system. Blood functions in two directions: arterial and venous. Arterial blood is the means by which oxygen and nutrients are transported to tissues while venous blood is the means by which carbon dioxide and metabolic by-products are transported to the lungs and kidneys, respectively, for removal from the body.

Botulinum toxin: A toxin produced by the bacterium Clostridium botulinum that is the most poisonous biological substance known. Botulinum toxin acts as a neurotoxin . It binds to the nerve ending at the point where the nerve joins a muscle, blocking the release by the nerve of the chemical acetylcholine (the principal neurotransmitter at the neuromuscular junction), preventing the muscle from contracting. The result is weakness and paralysis of the muscle. The muscle atrophies. The blockage of acetylcholine release is irreversible. Function can be recovered by the sprouting of nerve terminals and the formation of new synaptic contacts, which usually takes 2 to 3 months.
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Botulism: An uncommon but potentially very serious illness, a type of food poisoning , that produces paralysis of muscles, via a nerve toxin called botulinum toxin ("botox") that is manufactured by bacteria named Clostridium botulinum.
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Brain: That part of the central nervous system that is located within the cranium ( skull ). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."
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Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation.

Clostridium: A group of anaerobic bacteria (bacteria that thrive in the absence of oxygen ). There are 100+ species of Clostridium. They include, for examples, Clostridium difficile , Clostridium perfringens (also called Clostridium welchii), and Clostridium botulinum.
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Clostridium botulinum: A group of rod-shaped bacteria commonly found in the soil that grow best under low oxygen conditions. The bacteria form heat-resistant spores which allow them to survive in a dormant state until exposed to conditions that can support their growth. Clostridium botulinum produces botulinum toxin, a highly potent neurotoxin and the basis of the disease botulism .
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Contraction: The tightening and shortening of a muscle.

Diagnosis: 1 The nature of a disease ; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies . 3 The identification of any problem. The diagnosis was a plugged IV.
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Disease: Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

Dysphonia: An impairment of the voice. Difficulty in speaking. Hoarseness is a common sort of dysphonia. See also: Spasmodic dysphonia.

Dystonia: Involuntary movements and prolonged muscle contraction, resulting in twisting body motions, tremor, and abnormal posture. These movements may involve the entire body, or only an isolated area. Symptoms may even be "task specific," such as writer's cramp. Dystonia can be inherited, occur sporadically without any genetic pattern, or be associated with medications or diseases (for example, a specific form of lung cancer). The gene responsible for at least one form of dystonia has recently been identified. Some types of dystonia respond to dopamine, or can be controlled with sedative-type medications, or surgery.

Eyelid: The lid or cover of the eye, a movable fold of skin and muscle that can be closed over the eyeball or opened at will. Each eye has an upper and a lower lid. An eyelid is also called a palpebra.
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Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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Garlic: A perennial herb of the lily family cultivated for its pungent, edible bulbs. Garlic has been used with the intention of lowering blood pressure and cholesterol.
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Germ: 1. A cell or group of cells (called a primordium ) capable of developing into an organ , a part or an organism in its entirety. Eggs and sperm are germ cells .

2. A pathogenic a microorganism. A microbe capable of causing disease . The germ theory of disease held, correctly, that these minute bodies can cause disease.

3. The figurative source or wellspring. Dr. Watson told Holmes he had the germ of an idea.
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Guillain-Barré syndrome: See: Guillain-Barre syndrome.

Health: As officially defined by the World Health Organization, a state of complete physical, mental, and social well-being, not merely the absence of disease or infirmity.

Heroin: Semisynthetic drug derived from morphine. Discovered in 1874, it was introduced commercially in 1898 by the Bayer company in Germany. The name heroin was coined from the German heroisch meaning heroic, strong. Heroin is stronger (more potent) than morphine.
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Hospital: It may seem unnecessary to define a "hospital" since everyone knows the nature of a hospital. A hospital began as a charitable institution for the needy, aged, infirm, or young.
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Incidence: The frequency with which something, such as a disease, appears in a particular population or area. In disease epidemiology, the incidence is the number of newly diagnosed cases during a specific time period. The incidence is distinct from the prevalence which refers to the number of cases alive on a certain date.
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Infant: A child up to 2 years (24 months) of age.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Intestine: The long, tubelike organ in the abdomen that completes the process of digestion. It consists of the small and large intestines.

Knee: The knee is a joint which has three parts. The thigh bone (the femur) meets the large shin bone (the tibia) to form the main knee joint. This joint has an inner (medial) and an outer (lateral) compartment. The kneecap (the patella) joins the femur to form a third joint, called the patellofemoral joint. The patella protects the front of the knee joint.
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Knee jerk: The reflex tested by tapping just below the knee causing the lower leg to suddenly jerk forward.
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Lethal: Deadly, fatal, capable of causing death, death-dealing. The word "lethal" comes from the Latin "letum" meaning "death or destruction."

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Myasthenia gravis: An autoimmune neuromuscular disorder characterized by fatigue and exhaustion of muscles. Myasthenia gravis is caused by a mistaken immune response to the nicotinic acetylcholine receptors (AChR), which are found in junctions between muscles and the nervous system . The body produces antibodies that attack these AChR receptors, preventing signals from reaching the muscles. Proof that the anti-AChR antibodies are responsible for myasthenia comes from the effect these antibodies can have on the unborn and the newborn.
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Nerve: A bundle of fibers that uses chemical and electrical signals to transmit sensory and motor information from one body part to another. See: Nervous system.

Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
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Paralysis: Loss of voluntary movement (motor function). Paralysis that affects only one muscle or limb is partial paralysis, also known as palsy; paralysis of all muscles is total paralysis, as may occur in cases of botulism.

Poisoning: Taking a substance that is injurious to health or can cause death. Poisoning is still a major hazard to children, despite child-resistant (and sometimes adult-resistant) packaging and dose-limits per container.
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Public health: The approach to medicine that is concerned with the health of the community as a whole. Public health is community health. It has been said that: "Health care is vital to all of us some of the time, but public health is vital to all of us all of the time."
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Quarantine: The period of isolation decreed to control the spread of infectious disease. Before the era of antibiotics, quarantine was one of the few available means for halting the spread of infectious diseases. It is still employed as needed. The list of quarantinable diseases in the US includes cholera , diphtheria , infectious tuberculosis , plague , smallpox , yellow fever , and viral hemorrhagic fevers (such as Marburg, Ebola and Congo-Crimean disease). In 2003, SARS (severe acute respiratory syndrome) was added as a quarantinable disease.
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Reflex: A reaction that is involuntary. The corneal reflex is the blink that occurs with irritation of the eye. The nasal reflex is a sneeze.
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Respiratory: Having to do with respiration, the exchange of oxygen and carbon dioxide. From the Latin re- (again) + spirare (to breathe) = to breathe again.

Respiratory failure: Inability of the lungs to perform their basic task of gas exchange , the transfer of oxygen from inhaled air into the blood and the transfer of carbon dioxide from the blood into exhaled air. The basis of respiratory failure may be failure of the exchange of oxygen and carbon dioxide within the tiny air sacs (alveoli) in the lungs; failure of the muscles required to expand the lungs; or failure of the brain centers controlling respiration.
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Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
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Serum: The clear liquid that can be separated from clotted blood. Serum differs from plasma, the liquid portion of normal unclotted blood containing the red and white cells and platelets. It is the clot that makes the difference between serum and plasma.
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Spasmodic dysphonia: A voice disorder caused by involuntary movements of one or more muscles of the larynx or voice box. People who have spasmodic dysphonia may have occasional difficulty saying a word or two or they may experience sufficient difficulty to interfere with communication. Spasmodic dysphonia causes the voice to break or to have a tight, strained, strangled or effortful quality. Spasmodic dysphonia can affect anyone. It most often becomes evident between 30 and 50 years of age. More women are affected by spasmodic dysphonia than men. Also called spastic dysphonia and laryngeal dystonia .
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Stool: The solid matter discharged in a bowel movement.

Strabismus: A condition in which the visual axes of the eyes are not parallel and the eyes appear to be looking in different directions. In divergent strabismus, or exotropia, the visual axes diverge. If the visual axes converge, it is called convergent strabismus or esotropia. The danger with strabismus is that the brain cones may come to rely more on one eye than the other and that part of the brain circuitry connected to the less-favored eye fails to develop properly, leading to amblyopia (blindness) in that eye.
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Stroke : The sudden death of some brain cells due to a lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A stroke is also called a cerebrovascular accident or, for short, a CVA.
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Substance: 1. Material with particular features, as a pressor substance.
2. The material that makes up an organ or structure. Also known in medicine as the substantia.
3. A psychoactive drug as, for example, in substance abuse.

Supportive care: Treatment given to prevent, control, or relieve complications and side effects and to improve the patient's comfort and quality of life.

Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Tendon: The tissue by which a muscle attaches to bone. A tendon is somewhat flexible, but fibrous and tough. When a tendon becomes inflamed, the condition is referred to as tendinitis or tendonitis. Inflamed tendons are at risk for rupture.
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Therapy: The treatment of disease .
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Torticollis: The most common of the focal dystonias, torticollis is a state of excessive of inadequate muscle tone in the muscles in the neck that control the position of the head. It can cause the head to twist and turn to one side, and the head may also be pulled forward or backward.
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Toxin: One of a number of poisons produced by certain plants, animals, and bacteria.
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Ventilator: A ventilator is a machine which mechanically assists patients in the exchange of oxygen and carbon dioxide (sometimes referred to as artificial respiration).

From the Doctors at MedicineNet.com

Electromyogram - EMG (electromyogram) can detect abnormal muscle electrical activity in many diseases and conditions. Source:MedicineNet Botox - Botox is the brand name of a toxin produced by the bacterium Clostridium botulinum.Small, diluted amounts can be directly injected into specific muscles causing controlled weakening of the muscles. Source:WebMD Medical Reference from The Cleveland Clinic Food Poisoning - Read about the types of food poisoning from bacterium infection from Campylobacter, Salmonella, Shigella, E. coli O157:H7, Listeria, and botulism. Symptoms, diagnosis, treatment and prevention information is included in the information. Source:WebMD Medical Reference from The Cleveland Clinic Read 29 more Botulism related articles ... U.S. Food Safety: Foodborne Illnesses a Menu for Disaster FDA Checks Reports of Botox Risks U.S. Food Safety: A Grocery List of Tainted Products Beware Bogus Botox Botulism Recall Widened Botulism Risk in Some Canned Green Beans Botulism Risk Sparks Chili Sauce Recall