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February 10, 2012

Botulism Glossary of Terms

The following are health and medical definitions of terms that appear in the Botulism article.

Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer).

Acetylcholine: A key chemical in neurons (nerve cells) that acts as a neurotransmitter and carries information across the synaptic cleft, the space between two nerve cells. Abbreviated ACh.

Achalasia: A disease of the esophagus caused by the abnormal function of nerves and muscles of the esophagus that makes swallowing difficult. There may sometimes be chest pain. Regurgitation of undigested food can occur, as can coughing or breathing problems due to entry of food into the lungs. The underlying problems are weakness of the lower portion of the esophagus and failure of the lower esophageal sphincter to open and allow passage of food. Achalasia may occur at any age but is predominantly a disease of young adults. Diagnosis is made by an X-ray, endoscopy, or esophageal manometry (to measure the pressure in the esophagus). Treatment includes medication, dilation (stretching) to widen the lower part of the esophagus, and surgery to open the lower esophagus. A fairly recent approach involves injecting medicines into the lower esophagus to relax the sphincter.
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Acquired: Anything that is not present at birth but develops some time later. In medicine, the word "acquired" implies "new" or "added." An acquired condition is "new" in the sense that it is not genetic (inherited) and "added" in the sense that was not present at birth.
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Aerosol: 1. In general, a fine mist or spray which contains minute particles.
2. In medicine, a spray administered by a nebulizer and inhaled for treatment.
3. In medicine, a mist that causes disease as, for example, the hantavirus pulmonary syndrome.
4. In the environment, particles emitted into the air naturally as in volcanic eruptions and through human action such as burning fossil fuel.
5. In the environment, the pressurized gas used to propel substances out of a container.

Alternative medicine: Healing arts not taught in traditional Western medical schools that promote options to conventional medicine that is taught in these schools.. An example of an alternative therapy is using a special diet to treat cancer instead of undergoing surgery, radiation, or chemotherapy that has been recommended by a Western physician. Complementary medicine is different from alternative medicine. Whereas complementary medicine is used together with conventional medicine, alternative medicine is used in place of conventional medicine. See also complementary medicine, conventional medicine.

Aluminum: A naturally occurring element that makes up about 8% of the surface of the earth and is always found combined with other elements such as oxygen, silicon, and fluorine. Aluminum is is the most common metallic element in the earth's crust but has no clear biologic role. Everyone is exposed to low levels of aluminum from food, air, and water. Exposure to high levels of aluminum may result in respiratory problems (aluminosis). Inhalation of bauxite (aluminum ore) fumes may cause pulmonary fibrosis. Aluminum in the bloodstream may lead to neurological symptoms and may be fatal.
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Anaerobic: Not requiring oxygen. Anaerobic bacteria do not need oxygen to grow; in fact, oxygen is usually toxic to them. An anaerobic environment lacks oxygen.

Antitoxin: An antibody capable of destroying microorganisms including viruses and bacteria.
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Arms: An appendage in anatomy and in clinical trials. See: Arm.

Axon: A long fiber of a nerve cell (a neuron) that acts somewhat like a fiber-optic cable carrying outgoing (efferent) messages.
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Bacteria: Single-celled microorganisms which can exist either as independent (free-living) organisms or as parasites (dependent upon another organism for life).
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Bacterial: Of or pertaining to bacteria. For example, a bacterial lung infection.

Bacterium: The singular of bacteria.

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Bioterrorism: Terrorism using biologic agents that are harmful to humans. Biological diseases and the agents that might be used for terrorism have been listed by the US Centers for Disease Control and Prevention (CDC). These agents include viruses, bacteria, rickettsiae (microorganisms that have traits common to both bacterial and viruses), fungi, and biological toxins. The biological disease agents are classified into three categories, according to the degree of danger each agent is felt to pose.
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Blepharospasm: Involuntary forcible closure of the eyelids. The first symptom may be uncontrollable blinking. Only one eye may be affected initially, but eventually both eyes are usually involved. The spasms may leave the eyelids completely closed causing functional blindness even though the eyes and vision are normal. Blepharospasm is a form of focal dystonia.

Blurred vision: Lack of sharpness of vision with, as a result, the inability to see fine detail. Blurred vision can occur when a person who wears corrective lens is without them. Blurred vision can also be an important clue to eye disease.

Boil: A skin abscess, a collection of pus localized deep in the skin. A boil usually starts as a reddened, tender area and in time becomes firm and hard. Eventually, the center of the abscess softens and becomes filled with white blood cells that the body sends to fight the infection. This collection of white cells is the pus.
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Botox: A highly purified preparation of botulinum toxin A, a toxin produced by the bacterium Clostridium botulinum. Botox is for injection, in very small amounts, into specific muscles. It acts by blocking the transmission of nerve impulses to muscles and so paralyzing the muscles. Botox is a brand name that has passed into popular usage as a synonym for Botulinum toxin.
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Botulinum toxin: A toxin produced by the bacterium Clostridium botulinum that is the most poisonous biological substance known. Botulinum toxin acts as a neurotoxin. It binds to the nerve ending at the point where the nerve joins a muscle, blocking the release by the nerve of the chemical acetylcholine (the principal neurotransmitter at the neuromuscular junction), preventing the muscle from contracting. The result is weakness and paralysis of the muscle. The muscle atrophies. The blockage of acetylcholine release is irreversible. Function can be recovered by the sprouting of nerve terminals and the formation of new synaptic contacts, which usually takes 2 to 3 months.
See the entire definition of Botulinum toxin

Botulism: An uncommon but potentially very serious illness, a type of food poisoning, that produces paralysis of muscles, via a nerve toxin called botulinum toxin ("botox") that is manufactured by bacteria named Clostridium botulinum.
See the entire definition of Botulism

Brain: That part of the central nervous system that is located within the cranium (skull). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."

Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation.

CDC: The Centers for Disease Control and Prevention, the US agency charged with tracking and investigating public health trends. The stated mission of the CDC is "To promote health and quality of life by preventing and controlling disease, injury, and disability." The CDC is a part of the U.S. Public Health Services (PHS) under the Department of Health and Human Services (HHS).
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Centers for Disease Control and Prevention: The US agency charged with tracking and investigating public health trends. The stated mission of the Centers for Disease Control and Prevention, commonly called the CDC, is "To promote health and quality of life by preventing and controlling disease, injury, and disability."
See the entire definition of Centers for Disease Control and Prevention

Cervical: Having to do with any kind of neck including the neck on which the head is perched and the neck of the uterus. The word "cervix" in Latin means "neck". That is why cervical vertebrae and cervical cancer involve quite disparate parts of the anatomy joined only by the meaning of the word "cervix".

Clostridium: A group of anaerobic bacteria (bacteria that thrive in the absence of oxygen). There are 100+ species of Clostridium. They include, for examples, Clostridium difficile, Clostridium perfringens (also called Clostridium welchii), and Clostridium botulinum.
See the entire definition of Clostridium

Clostridium botulinum: A group of rod-shaped bacteria commonly found in the soil that grow best under low oxygen conditions. The bacteria form heat-resistant spores which allow them to survive in a dormant state until exposed to conditions that can support their growth. Clostridium botulinum produces botulinum toxin, a highly potent neurotoxin and the basis of the disease botulism.
See the entire definition of Clostridium botulinum

Constipation: Infrequent (and frequently incomplete) bowel movements. The opposite of diarrhea, constipation is commonly caused by irritable bowel syndrome, diverticulosis, and medications (constipation can paradoxically be caused by overuse of laxatives). Colon cancer can narrow the colon and thereby cause constipation. The large bowel (colon) can be visualized by barium enema x-rays, sigmoidoscopy, and colonoscopy. Barring a condition such as cancer, high-fiber diets can frequently relieve the constipation.

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Cuts: Severed skin. Washing a cut or scrape with soap and water and keeping it clean and dry is all that is required to care for most wounds. Putting alcohol hydrogen peroxide, and iodine into a wound can delay healing and should be avoided. Seek medical care early if you think that you might need stitches. Any delay can increase the rate of wound infection. Any puncture wound through tennis shoes has a high risk of infection and should be seen by your healthcare professional. Any redness, swelling, increased pain, or pus draining from the wound may indicate an infection that requires professional care.

Detoxify: To reduce or eliminate the toxicity of a substance or poison. To promote the recovery of a person from an addictive drug such as alcohol or heroin.

Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV.
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Dry mouth: The condition of not having enough saliva to keep the mouth wet. This is due to inadequate function of the salivary glands. Everyone has dry mouth once in a while when they are nervous, upset or under stress. But if someone has a dry mouth most all of the time, it can be uncomfortable and lead to serious health problems.
See the entire definition of Dry mouth

Dysphasia: One in a group of speech disorders in which there is impairment of the power of expression by speech, writing, or signs, or impairment of the power of comprehension of spoken or written language. More severe forms of dysphasia are called aphasia.
See the entire definition of Dysphasia

Dysphonia: An impairment of the voice. Difficulty in speaking. Hoarseness is a common sort of dysphonia. See also: Spasmodic dysphonia.

Dystonia: Involuntary movements and prolonged muscle contraction, resulting in twisting body motions, tremor, and abnormal posture. These movements may involve the entire body, or only an isolated area. Symptoms may even be "task specific," such as writer's cramp. Dystonia can be inherited, occur sporadically without any genetic pattern, or be associated with medications or diseases (for example, a specific form of lung cancer). The gene responsible for at least one form of dystonia has recently been identified. Some types of dystonia respond to dopamine, or can be controlled with sedative-type medications, or surgery.

Eyelid: The lid or cover of the eye, a movable fold of skin and muscle that can be closed over the eyeball or opened at will. Each eye has an upper and a lower lid. An eyelid is also called a palpebra.

Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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FDA: The Food and Drug Administration, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services.
See the entire definition of FDA

FEMA: A name well known to people in the US who have experienced a major natural or made-man disaster. FEMA stands for Federal Emergency Management Agency.

Food and Drug Administration: The FDA, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services.
See the entire definition of Food and Drug Administration

Food poisoning: A common flu-like illness typically characterized by nausea, vomiting and diarrhea, due to something the victim ate or drank that contained noxious bacteria, viruses, parasites, metals or toxins.
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Garlic: A perennial herb of the lily family cultivated for its pungent, edible bulbs. Garlic has been used with the intention of lowering blood pressure and cholesterol.
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Gram-positive: Gram-positive bacteria retain the color of the crystal violet stain in the Gram stain. This is characteristic of bacteria that have a cell wall composed of a thick layer of a particular substance (called peptidologlycan).
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Heroin: Semisynthetic drug derived from morphine. Discovered in 1874, it was introduced commercially in 1898 by the Bayer company in Germany. The name heroin was coined from the German heroisch meaning heroic, strong. Heroin is stronger (more potent) than morphine.

Immune: Protected against infection. The Latin immunis means free, exempt.

Immunity: The condition of being immune. Immunity can be innate (for example, humans are innately immune to canine distemper) or conferred by a previous infection or immunization.

Incidence: The frequency with which something, such as a disease, appears in a particular population or area. In disease epidemiology, the incidence is the number of newly diagnosed cases during a specific time period. The incidence is distinct from the prevalence which refers to the number of cases alive on a certain date.

Infant: A child up to 2 years (24 months) of age.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Intestine: The long, tubelike organ in the abdomen that completes the process of digestion. It consists of the small and large intestines.

Knee-jerk: Adjective meaning readily predictable to the point of being automatic. Knee-jerk often has a negative connotation and conveys the idea of an all-too-hasty, impulsive, irrational response based on a preset idea. For example, a dictator's knee-jerk response to a democratic movement is to suppress it. The term is derived from the reaction which has been so often tested as to become a familiar figure of speech.
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Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."

Lethal: Deadly, fatal, capable of causing death, death-dealing. The word "lethal" comes from the Latin "letum" meaning "death or destruction."

Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.


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Motor: In medicine, having to do with the movement of a part of the body. Something that produces motion or refers to motion. For example, a motor neuron is a nerve cell that conveys an impulse to a muscle causing it to contract. The term "motor" today is also applied to a nerve that signals a gland to secrete. Motor is as opposed to sensory.

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Myasthenia gravis: An autoimmune neuromuscular disorder characterized by fatigue and exhaustion of muscles. Myasthenia gravis is caused by a mistaken immune response to the nicotinic acetylcholine receptors (AChR), which are found in junctions between muscles and the nervous system. The body produces antibodies that attack these AChR receptors, preventing signals from reaching the muscles. Proof that the anti-AChR antibodies are responsible for myasthenia comes from the effect these antibodies can have on the unborn and the newborn.
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Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleeding, a physician should be consulted.

Nerve: A bundle of fibers that uses chemical and electrical signals to transmit sensory and motor information from one body part to another. See: Nervous system.

Neuromuscular: Pertaining to both nerves and muscles, as in neuromuscular blockade by an anesthetic agent, the neuromuscular junction (the meeting place of a nerve and a muscle fiber), and neuromuscular transmission (the transfer of "information" from the nerve to the muscle).

Neurotoxin: A substance that causes damage to nerves or nerve tissue. For example, lead is a neurotoxin.

Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

Oromandibular dystonia: Oro- refers to the mouth and mandibular refers to the lower jaw. Oromandibular dystonia affects the muscles of the jaw, lips, and tongue. The jaw may be pulled either open or shut, and speech and swallowing can be difficult.

Orphan drug: A drug designed to treat or prevent an orphan disease.

Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
See the entire definition of Pain

Paralysis: Loss of voluntary movement (motor function). Paralysis that affects only one muscle or limb is partial paralysis, also known as palsy; paralysis of all muscles is total paralysis, as may occur in cases of botulism.

Peritoneal: Having to do with the peritoneum.

Poisoning: Taking a substance that is injurious to health or can cause death. Poisoning is still a major hazard to children, despite child-resistant (and sometimes adult-resistant) packaging and dose-limits per container.
See the entire definition of Poisoning

Ptosis: Downward displacement. Ptosis of the eyelids is drooping of the eyelids.

Quarantine: The period of isolation decreed to control the spread of infectious disease. Before the era of antibiotics, quarantine was one of the few available means for halting the spread of infectious diseases. It is still employed as needed. The list of quarantinable diseases in the US includes cholera, diphtheria, infectious tuberculosis, plague, smallpox, yellow fever, and viral hemorrhagic fevers (such as Marburg, Ebola and Congo-Crimean disease). In 2003, SARS (severe acute respiratory syndrome) was added as a quarantinable disease.
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Reflex: A reaction that is involuntary. The corneal reflex is the blink that occurs with irritation of the eye. The nasal reflex is a sneeze.

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Regenerate: To reproduce or renew something lost. For example, after an injury, the liver has the capacity to regenerate.

Respiratory: Having to do with respiration, the exchange of oxygen and carbon dioxide. From the Latin re- (again) + spirare (to breathe) = to breathe again.

Respiratory failure: Inability of the lungs to perform their basic task of gas exchange, the transfer of oxygen from inhaled air into the blood and the transfer of carbon dioxide from the blood into exhaled air. The basis of respiratory failure may be failure of the exchange of oxygen and carbon dioxide within the tiny air sacs (alveoli) in the lungs; failure of the muscles required to expand the lungs; or failure of the brain centers controlling respiration.
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Salmonella: A group of bacteria that cause typhoid fever and a number of other illnesses, including food poisoning, gastroenteritis and enteric fever from contaminated food products.
See the entire definition of Salmonella

Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
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Serum: The clear liquid that can be separated from clotted blood. Serum differs from plasma, the liquid portion of normal unclotted blood containing the red and white cells and platelets. It is the clot that makes the difference between serum and plasma.
See the entire definition of Serum

Shortness of breath: Difficulty in breathing. Medically referred to as dyspnea. Shortness of breath can be caused by respiratory (breathing passages and lungs) or circulatory (heart and blood vessels) conditions. See also dyspnea.

Spasm: A brief, automatic jerking movement. A muscle spasm can be quite painful, with the muscle clenching tightly. A spasm of the coronary artery can cause angina. Spasms in various types of tissue may be caused by stress, medication, over-exercise, or other factors.

Spasmodic dysphonia: A voice disorder caused by involuntary movements of one or more muscles of the larynx or voice box. People who have spasmodic dysphonia may have occasional difficulty saying a word or two or they may experience sufficient difficulty to interfere with communication. Spasmodic dysphonia causes the voice to break or to have a tight, strained, strangled or effortful quality. Spasmodic dysphonia can affect anyone. It most often becomes evident between 30 and 50 years of age. More women are affected by spasmodic dysphonia than men. Also called spastic dysphonia and laryngeal dystonia.
See the entire definition of Spasmodic dysphonia

Stool: The solid matter discharged in a bowel movement.

Strabismus: A condition in which the visual axes of the eyes are not parallel and the eyes appear to be looking in different directions. In divergent strabismus, or exotropia, the visual axes diverge. If the visual axes converge, it is called convergent strabismus or esotropia. The danger with strabismus is that the brain cones may come to rely more on one eye than the other and that part of the brain circuitry connected to the less-favored eye fails to develop properly, leading to amblyopia (blindness) in that eye.
See the entire definition of Strabismus

Stroke: The sudden death of some brain cells due to a lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A stroke is also called a cerebrovascular accident or, for short, a CVA.
See the entire definition of Stroke

Supportive care: Treatment given to prevent, control, or relieve complications and side effects and to improve the patient's comfort and quality of life.

Sweating: The act of secreting fluid from the skin by the sweat (sudoriferous) glands. These are small tubular glands situated within and under the skin (in the subcutaneous tissue). They discharge by tiny openings in the surface of the skin.
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Symptom: Any subjective evidence of disease. Anxiety, lower back pain, and fatigue are all symptoms. They are sensations only the patient can perceive. In contrast, a sign is objective evidence of disease. A bloody nose is a sign. It is evident to the patient, doctor, nurse and other observers.

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Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Tendon: The tissue by which a muscle attaches to bone. A tendon is somewhat flexible, but fibrous and tough. When a tendon becomes inflamed, the condition is referred to as tendinitis or tendonitis. Inflamed tendons are at risk for rupture.
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Tetanus: An often fatal infectious disease caused by the bacteria Clostridium tetani (C. tetani) which usually enters the body through a puncture, cut, or open wound. Tetanus is characterized by profoundly painful spasms of muscles, including "locking" of the jaw so that the mouth cannot open (lockjaw). C. tetani releases a toxin that affects the motor nerves, (the nerves which stimulate the muscles).
See the entire definition of Tetanus

Therapeutic: Relating to therapeutics, that part of medicine concerned specifically with the treatment of disease. The therapeutic dose of a drug is the amount needed to treat a disease.
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Therapy: The treatment of disease.
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Torticollis: The most common of the focal dystonias, torticollis is a state of excessive of inadequate muscle tone in the muscles in the neck that control the position of the head. It can cause the head to twist and turn to one side, and the head may also be pulled forward or backward.
See the entire definition of Torticollis

Toxin: One of a number of poisons produced by certain plants, animals, and bacteria.
See the entire definition of Toxin

Ventilator: A ventilator is a machine which mechanically assists patients in the exchange of oxygen and carbon dioxide (sometimes referred to as artificial respiration).

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Botulism

What is an electromyogram?

An electromyogram (EMG) is a test that is used to record the electrical activity of muscles. When muscles are active, they produce an electrical current. This current is usually proportional to the level of the muscle activity. An EMG is also referred to as a myogram.

EMGs can be used to detect abnormal electrical activity of muscle that can occur in many diseases and conditions, including muscular dystrophy, inflammation of muscles, pinched nerves, peripheral nerve damage (damage to nerves in the arms and legs), amyotrophic lateral sclerosis (ALS), myasthenia gravis, disc herniation, and others.

Why is an EMG test done?

An EMG is often performed when patients have unexplained muscle weakness. The EMG helps to distinguish between muscle conditions in which the problem begins in the muscle and muscle weakness due to nerve disorders. The EMG can also be used to detect true weakness, as ...

Read the Electromyogram (EMG) article »







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