onabotulinumtoxinA, Botox, Botox Cosmetic (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
It is injected into the muscles that control the eyeball for treating strabismus (misaligned or lazy eyes) and the muscles of the eyelid for treating blepharospasm (uncontrollable blinking) associated with a condition called dystonia.
It also is effective for managing urinary incontinence associated with neurologic conditions such as multiple sclerosis for which it is injected into the muscular bladder wall to prevent involuntary muscular spasm that leads to incontinence (uncontrollable urination). B
Botox cosmetic is used for reducing glabellar lines (frown lines) in adults 65 years of age or younger.
DOSING: OnabotulinumtoxinA is giving by intramuscular injection. Dosing should be individualized (based on its purpose and the patient in whom it is being used), and the lowest effective dose should be used. OnabotulinumtoxinA is not interchangeable with other preparations of botulinum toxin.
DRUG INTERACTIONS: Administration of onabotulinumtoxinA with other agents (for example, aminoglycosides, curare) that affect neuromuscular function may increase the effect of onabotulinumtoxinA. Use of muscle relaxants may increase the occurrence of weakness. Use of drugs that block acetylcholine may increase some effects of onabotulinumtoxinA.
PREGNANCY: There are no adequate studies of onabotulinumtoxinA in pregnant women.
NURSING MOTHERS: OnabotulinumtoxinA has not been evaluated in nursing mothers
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