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- What is botulinum toxin type A, and how does it work (mechanism of action)?
- What brand names are available for botulinum toxin type A?
- Is botulinum toxin type A available as a generic drug?
- Do I need a prescription for botulinum toxin type A?
- What are the side effects of botulinum toxin type A?
- What is the dosage for botulinum toxin type A?
- Which drugs or supplements interact with botulinum toxin type A?
- Is botulinum toxin type A safe to take if I'm pregnant or breastfeeding?
- What else should I know about botulinum toxin type A?
What is botulinum toxin type A, and how does it work (mechanism of action)?
OnabotulinumtoxinA is an injectable neuro-toxin, that is, a toxic chemical that blocks the ability of nerves to make muscles contract. In other words, it paralyzes muscles.
To cause muscles to contract, nerves release a chemical, acetylcholine, where they meet muscle cells. The acetylcholine attaches to receptors on the muscle cells and causes the muscle cells to contract or shorten. OnabotulinumtoxinA prevents the release of acetylcholine and thereby prevents contraction of the muscle cells. In order to affect the release of acetylcholine, onabotulinumtoxinA must be injected into the muscle. OnabotulinumtoxinA was approved by the FDA in December 1991.
What brand names are available for botulinum toxin type A?
Botox, Botox Cosmetic
Is botulinum toxin type A available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for botulinum toxin type A?
What are the side effects of botulinum toxin type A?
Side effects of onabotulinumtoxinA include:
- allergic reactions,
- neck pain,
- difficulty swallowing,
- shortness of breath,
- weakness, and dry mouth.
Patients also complain of pain and tenderness at the injection site. Patients treated for blepharospasm may experience
- drooping of the eyelid (ptosis),
- inflammation of the cornea (keratitis),
- eye dryness,
- double vision,
- and sensitivity to light.
Those treated for urinary incontinence may experience:
- difficulty urinating.
- Heart attacks,
- abnormal heart beats, and
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