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November 8, 2009
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The Cleveland Clinic

Breast Cancer: Bone Marrow Transplantation

A bone marrow transplant may be used to treat patients with certain forms of cancer, such as leukemia, lymphoma, or breast cancer. The goal of such a transplant in women with breast cancer is to allow them to undergo high-dose chemotherapy -- which aggressively attacks the cancer cells, but also damages normal blood cells - and then replace the damaged cells with healthy ones.

What Is Bone Marrow?

Bone marrow is the spongy tissue found inside bone. The bone marrow in the breastbone, skull, hips, ribs, and spine contains stem cells that produce the body's blood cells. The three kinds of blood cells that the body needs to function -- oxygen-carrying red blood cells, infection-fighting white blood cells, and clot-forming platelets -- are all made in the bone marrow.

Who Is A Candidate For A Bone Marrow Transplant?

The decision to prescribe a bone marrow transplant is always made on an individual basis. Your doctor will consider your age, general physical condition, diagnosis, and stage of disease. Your doctor will also make sure you understand the potential benefits and risks of the transplant procedure.



Next: Where does the transplanted bone marrow come from? »

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Bone Marrow Transplantation for Breast Cancer

Introduction

Younger women generally do not consider themselves to be at risk for breast cancer. Only 5 percent of all breast cancer cases occur in women under 40 years old. However, breast cancer can strike at any age, and all women should be aware of their personal risk factors for breast cancer. (A risk factor is a condition or behavior that puts a person at risk for developing a disease.)

There are several factors that put a woman at high risk for developing breast cancer, including:

Risk factors include:

  • A personal history of breast cancer or non-cancerous breast disease
  • A family history of breast cancer, particularly in a mother, daughter or sister
  • History of radiation therapy Evidence of a specific genetic defect (BRCA1/BRCA2 mutation). Women who carry defects on either of these genes are at greater risk for developing bre...

Read the Breast Cancer in Young Women article »










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