boceprevir (Victrelis)

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GENERIC NAME: boceprevir

BRAND NAME: Victrelis

DRUG CLASS AND MECHANISM: Boceprevir is a man-made antiviral medication that targets hepatitis C virus (HCV). Similar drugs include simeprevir (Olysio) and telaprevir (Incivek). These drugs are called direct-acting antiviral agents because they act directly on hepatitis C virus. They block the replication of hepatitis C virus in human cells by binding to and inhibiting protease enzymes that HCV use for reproducing. Inhibiting viral replication reduces HCV viral load in the body to undetectable levels in some patients. The FDA approved boceprevir in March 2011.



PREPARATIONS: Capsule, 200 mg

STORAGE: Boceprevir should be refrigerated at 2 C to 8 C (36 F 46 F) until dispensed. Refrigerated boceprevir can remain stable until the expiration date. Boceprevir can also be stored at room temperature up to 25 C (77 F) for 3 months. Boceprevir should be stored in tightly closed containers, avoiding exposure to excessive heat.

PRESCRIBED FOR: Boceprevir is used for chronic hepatitis C genotype 1 infection, in combination with peginterferon alfa and ribavirin (Rebetol, Copegus) in adults with compensated liver disease who have not been treated before or failed previous treatment.


Adults (18 years of age and older): The recommended dose of boceprevir is four 200 mg capsules (800 mg) by mouth three times daily approximately every 7 to 9 hours with a meal or light snack. Food increases the absorption of boceprevir.

Therapy is initiated with peginterferon alfa and ribavirin for 4 weeks, then boceprevir is added to peginterferon alfa and ribavirin regimen. The duration of treatment is based on viral response, prior response status and presence of cirrhosis.

Safe and effective use of boceprevir in patients under 18 years of age is not established. 

DRUG INTERACTIONS: Boceprevir should not be combined with alfuzosin (Uroxatral), doxazosin (Cardura), sildosin (Rapaflo), tamsulosin (Flomax), sildenafil (Viagra), and tadalafil (Cialis) because it can increase their blood levels, leading to increased side effects from these drugs.

Boceprevir should not be combined with carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, and St. John's wort because they can increase the breakdown of boceprevir and decrease its effectiveness.

Boceprevir should not be combined with lovastatin (Mevacor) and simvastatin (Zocor) due to increased risk of muscle aches, including rhabdomyolysis.

Boceprevir should be combined with midazolam (Versed) and triazolam (Halcion) because of increased risk of sedation and respiratory depression.

Boceprevir should be used with caution with HIV medications like atazanavir (Reyataz), ritonavir, (Norvir), darunavir (Prezista), and lopinavir/ritonavir (Kaletra) because it leads to fluctuating levels of boceprevir and the HIV medications, leading to decreased effectiveness.

Medically Reviewed by a Doctor on 7/18/2014

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