Blood Clots

  • Medical Author:
    Benjamin Wedro, MD, FACEP, FAAEM

    Dr. Ben Wedro practices emergency medicine at Gundersen Clinic, a regional trauma center in La Crosse, Wisconsin. His background includes undergraduate and medical studies at the University of Alberta, a Family Practice internship at Queen's University in Kingston, Ontario and residency training in Emergency Medicine at the University of Oklahoma Health Sciences Center.

  • Medical Editor: Melissa Conrad Stöppler, MD
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Quick GuideDeep Vein Thrombosis (DVT): Symptoms, Treatment & Prevention

Deep Vein Thrombosis (DVT): Symptoms, Treatment & Prevention

What are blood clots? What does a blood clot look like?

Blood flows through blood vessels (arteries and veins), and is constantly in motion as the heart pumps blood through arteries to the different areas (organs, glands, cells etc.) of the body. Blood is then returned back to the heart by the veins. Blood returns to the heart by the motion of the body. Muscles squeeze blood through the veins back toward the heart. Without motion, blood has a tendency to stagnate by gravity, which then has the tendency to clot.

Blood clotting is an important mechanism to help the body repair injured blood vessels. Blood consists of

  • red blood cells containing hemoglobin that carry oxygen to cells and remove carbon dioxide (the waste product of metabolism),
  • white blood cells that fight infection,
  • platelets that are part of the clotting process of the body, and
  • blood plasma, which contains fluid, chemicals and proteins that are important for bodily functions.

Complex mechanisms exist in the bloodstream to form clots where they are needed. If the lining of the blood vessels becomes damaged, platelets are recruited to the injured area to form an initial plug. These activated platelets release chemicals that start the clotting cascade, using a series of clotting factors produced by the body. Ultimately, fibrin is formed, the protein that crosslinks with itself to form a mesh that makes up the final blood clot.

The medical term for a blood clot is a thrombus (plural=thrombi). When a thrombus is formed as part of a normal repair process of the body, there is little consequence. Unfortunately, there are times when a thrombus (blood clot) will form when it is not needed, and this can have potentially significant consequences. Continue Reading

Reviewed on 4/27/2016
References
REFERENCES:

Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2_suppl):

Dzsheka MS, et al. Stroke and bleeding risk in atrial fibrillation. Clin Cardiol.2014, Oct, 37(10)

Medscape. Deep Vein Thrombosis and Thrombophlebitis.

Fauci, Anthony S., et al. Harrison's Principles of Internal Medicine. 17th ed. United States: McGraw-Hill Professional, 2011.

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