SIDE EFFECTS: The most common side effects are:
- low potassium,
- low blood pressure,
- reduced heart rate, and
- increased blood glucose.
Serious side effects of Ziac include:
- congestive heart failure,
- heart block,
- severely reduced heart rate,
- abnormal heart rhythms, and
- serious skin reactions.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets (bisoprolol/hydrochlorothiazide): 2.5/6.25 mg, 5/6.25 mg, and 10/6.25 mg.
STORAGE: Ziac should be stored at room temperature, 59 F - 86 F (15 C - 30 C) in a tight container.
DOSING: The dose of Ziac is tailored to the patient's needs. The initial dose is 2.5/6.25 mg daily. The dose may be increased very two weeks and the maximum dose is 20/12.5 mg once daily.
DRUG INTERACTIONS: Rifampin may increase the metabolism (destruction) of bisoprolol, possibly making bisoprolol less effective. Certain calcium channel blockers (CCBs), especially verapamil (Calan, Isoptin) and diltiazem (Cardizem, Tiazac), may enhance the effect of bisoprolol on the heart. In some patients, this may cause excessive slowing of the heart rate or reduce the heart's ability to beat. The use of digoxin (Lanoxin) with bisoprolol also may cause an excessive reduction in heart rate.
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