bisoprolol and hydrochlorothiazide, Ziac (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Ziac is used for treating patients with high blood pressure who have not adequately responded to either individual agent alone.
SIDE EFFECTS: The most common side effects are:
Serious side effects of Ziac include:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets (bisoprolol/hydrochlorothiazide): 2.5/6.25 mg, 5/6.25 mg, and 10/6.25 mg.
STORAGE: Ziac should be stored at room temperature, 59 F - 86 F (15 C - 30 C) in a tight container.
DOSING: The dose of Ziac is tailored to the patient's needs. The initial dose is 2.5/6.25 mg daily. The dose may be increased very two weeks and the maximum dose is 20/12.5 mg once daily.
DRUG INTERACTIONS: Rifampin may increase the metabolism (destruction) of bisoprolol, possibly making bisoprolol less effective. Certain calcium channel blockers (CCBs), especially verapamil (Calan, Isoptin) and diltiazem (Cardizem, Tiazac), may enhance the effect of bisoprolol on the heart. In some patients, this may cause excessive slowing of the heart rate or reduce the heart's ability to beat. The use of digoxin (Lanoxin) with bisoprolol also may cause an excessive reduction in heart rate.
Medically Reviewed by a Doctor on 5/15/2015
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Back to Medications Index
- Allergic Skin Disorders
- Bacterial Skin Diseases
- Bites and Infestations
- Diseases of Pigment
- Fungal Skin Diseases
- Medical Anatomy and Illustrations
- Noncancerous, Precancerous & Cancerous Tumors
- Oral Health Conditions
- Papules, Scales, Plaques and Eruptions
- Scalp, Hair and Nails
- Sexually Transmitted Diseases (STDs)
- Vascular, Lymphatic and Systemic Conditions
- Viral Skin Diseases
- Additional Skin Conditions