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- What is bisoprolol and hydrochlorothiazide, and how does it work (mechanism of action)?
- What brand names are available for bisoprolol and hydrochlorothiazide?
- Is bisoprolol and hydrochlorothiazide available as a generic drug?
- Do I need a prescription for bisoprolol and hydrochlorothiazide?
- What are the side effects of bisoprolol and hydrochlorothiazide?
- What is the dosage for bisoprolol and hydrochlorothiazide?
- Which drugs or supplements interact with bisoprolol and hydrochlorothiazide?
- Is bisoprolol and hydrochlorothiazide safe to take if I'm pregnant or breastfeeding?
- What else should I know about bisoprolol and hydrochlorothiazide?
What is the dosage for bisoprolol and hydrochlorothiazide?
The dose of Ziac is tailored to the patient's needs. The initial dose is 2.5/6.25 mg daily. The dose may be increased very two weeks and the maximum dose is 20/12.5 mg once daily.
Which drugs or supplements interact with bisoprolol and hydrochlorothiazide?
Rifampin may increase the metabolism (destruction) of bisoprolol, possibly making bisoprolol less effective. Certain calcium channel blockers (CCBs), especially verapamil (Calan, Isoptin) and diltiazem (Cardizem, Tiazac), may enhance the effect of bisoprolol on the heart. In some patients, this may cause excessive slowing of the heart rate or reduce the heart's ability to beat. The use of digoxin (Lanoxin) with bisoprolol also may cause an excessive reduction in heart rate.
Hydrochlorothiazide reduces the elimination of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity. Nonsteroidal anti-inflammatory drugs, for example, ibuprofen, may reduce the blood pressure effects of hydrochlorothiazide.
Combining HCTZ with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. Low blood potassium can increase the toxicity of digoxin (Lanoxin). Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by 43%-85%.
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