GENERIC NAME: bisoprolol and hydrochlorothiazide
BRAND NAME: Ziac
DRUG CLASS AND MECHANISM: Ziac is a combination product containing bisoprolol (Zebeta) and hydrochlorothiazide (HCTZ). Bisoprolol is a beta-adrenergic receptor blocking agent used for treating high blood pressure and heart pain (angina). Bisoprolol prevents the neurotransmitters (chemicals that nerves use to communicate with other nerves), norepinephrine and epinephrine (adrenaline), from binding to beta adrenergic receptors on nerves. By blocking the effect of norepinephrine and epinephrine on the nerves reaching the heart and blood vessels, beta blockers reduce heart rate and the force with which the heart contracts and reduce blood pressure by dilating blood vessels. It also may constrict air passages by stimulating the muscles that surround the air passages. Hydrochlorothiazide (HCTZ) is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid. It works by blocking salt and fluid reabsorption in the kidneys, causing increased urine output (diuresis). The mechanism of its action in lowering high blood pressure is not well understood. The combination of bisoprolol and HCTZ reduces blood pressure better than either drug alone. Ziac was approved in March 1993.
PRESCRIBED FOR: Ziac is used for treating patients with high blood pressure who have not adequately responded to either individual agent alone.
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