bisoprolol, Zebeta (cont.)

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 5 and 10 mg.

STORAGE: Bisoprolol should be stored at room temperature, 15 C to 30 C (59 F to 86 F) in an air-tight container.

PRESCRIBED FOR: Bisoprolol is used alone or with other drugs for treating patients with high blood pressure. It also is used for treating angina and congestive heart failure.

DOSING:

  • The usual adult dose of bisoprolol for treating high blood pressure (hypertension) is 2.5-20 mg once daily.
  • The dose for treating heart failure is 1.25 mg daily, not to exceed 10 mg a day.

DRUG INTERACTIONS: Rifampin may increase the metabolism (destruction) of bisoprolol, possibly making bisoprolol less effective. Certain calcium channel blockers (CCBs), especially verapamil (Calan, Isoptin) and diltiazem (Cardizem, Tiazac), may enhance the effect of bisoprolol on the heart. In some patients, this may cause excessive slowing of the heart rate or reduce the heart's ability to beat. The use of digoxin (Lanoxin) with bisoprolol also may cause an excessive reduction in heart rate.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil) and naproxen (Naprosyn, Anaprox, Aleve), can reduce the blood pressure lowering effects of beta- blockers.

PREGNANCY: There are no adequate studies in pregnant women.

NURSING MOTHERS: It is not known if bisoprolol is secreted in breast milk.

SIDE EFFECTS: Bisoprolol is generally well-tolerated, and side effects are mild and transient. Side effects include abdominal cramps, diarrhea, dizziness, fatigue, depression, headache, nausea,, impotence, slow heart rate, low blood pressure,, numbness, tingling, cold extremities, sore throat, and shortness of breath or wheezing. Patients with asthma may have symptoms increase.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 8/27/2014


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