bisoprolol, Zebeta (cont.)

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Medical and Pharmacy Editor:

Bisoprolol can aggravate breathing difficulties in patients with asthma, or chronic bronchitis and emphysema that have a component of bronchial spasm. In patients with existing slow heart rates (bradycardias) and heart blocks (defects in the electrical conduction within the heart), bisoprolol can cause dangerously slow heart rates and even shock. Bisoprolol reduces the force of contraction of heart muscle and can aggravate symptoms of heart failure. In patients with coronary artery disease, abruptly stopping bisoprolol can suddenly worsen angina and occasionally cause heart attacks. If it is necessary to discontinue bisoprolol, its dosage can be reduced gradually over one to two weeks. Bisoprolol can mask the early warning symptoms of low blood sugar (hypoglycemia), and should be used with caution in patients receiving treatment for diabetes.

Reference: FDA Prescribing Information

Last Editorial Review: 9/2/2009

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