SIDE EFFECTS: Bisoprolol is generally well-tolerated, and side effects are mild and transient. Side effects include:
- abdominal cramps,
- slow heart rate,
- low blood pressure,
- cold extremities,
- sore throat, and
- shortness of breath or
Patients with asthma may have symptoms increase.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 5 and 10 mg.
STORAGE: Bisoprolol should be stored at room temperature, 15 C to 30 C (59 F to 86 F) in an air-tight container.
- The usual adult dose of bisoprolol for treating high blood pressure (hypertension) is 2.5-20 mg once daily.
- The dose for treating heart failure is 1.25 mg daily, not to exceed 10 mg a day.
DRUG INTERACTIONS: Rifampin may increase the metabolism (destruction) of bisoprolol, possibly making bisoprolol less effective. Certain calcium channel blockers (CCBs), especially verapamil (Calan, Isoptin) and diltiazem (Cardizem, Tiazac), may enhance the effect of bisoprolol on the heart. In some patients, this may cause excessive slowing of the heart rate or reduce the heart's ability to beat. The use of digoxin (Lanoxin) with bisoprolol also may cause an excessive reduction in heart rate.
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