bicalutamide, Casodex (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Bicalutamide may interact with warfarin (Coumadin). Therefore, the dose of warfarin may need to be adjusted, and the ability of blood to clot should be closely monitored.

Bicalutamide reduces the activity of liver enzymes that breakdown certain drugs, for example, midazolam (Versed). Such combinations should be avoided if possible.

PREGNANCY: Bicalutamide is not used for treating women.

NURSING MOTHERS: Bicalutamide is not used for treating women.

SIDE EFFECTS: When bicalutamide and an LHRH analog are given together, the most common side effect is hot flashes (50% of patients) and facial flushing. Alcohol may worsen this reaction, and so it should be cautiously consumed. Other common side effects of the combination are infections, water retention, anemia diarrhea, constipation and overall pain including pain in the back, hips, and stomach. LHRH analogs may increase blood glucose and worsen diabetes. Less common side effects are breast enlargement and breast pain, which may be due to the bicalutamide alone.

Reference: FDA Prescribing Information

Last Editorial Review: 11/16/2012

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