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bexarotene - oral, Targretin (cont.)

PRECAUTIONS: Before taking bexarotene, tell your doctor or pharmacist if you are allergic to it; or to other retinoids such as isotretinoin, acitretin, etretinate, tretinoin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.This medication should not be used if you have certain medical conditions. Before taking this medicine, consult your doctor or pharmacist if you have: pancreatitis.Before using this medication, tell your doctor or pharmacist your medical history, especially of: frequent alcohol use, cataracts, high blood fats (high cholesterol/triglyceride), diabetes, gallbladder disease, liver problems, thyroid problems (e.g., hypothyroidism).This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.Because this medication can lower your body's ability to fight an infection, wash your hands frequently to prevent the spread of infection.This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. (See also Warning section.)It is not known if this drug passes into breast milk. Due to the possible harm to the nursing infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medication because a very serious interaction may occur: gemfibrozil.If you are currently using the medication listed above, tell your doctor or pharmacist before starting bexarotene.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: tamoxifen, vitamins/supplements that contain vitamin A, drugs affecting liver enzymes that remove bexarotene from your body (e.g., azole antifungals such as itraconazole/ketoconazole, macrolide antibiotics such as clarithromycin/erythromycin, cimetidine, rifamycins including rifabutin, St. John's wort, certain anti-seizure medicines such as phenytoin/phenobarbital).This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. You should use an additional form of reliable birth control while using this medication. (See also Warning section.) Consult your doctor or pharmacist for details.This medication may interfere with certain laboratory tests (including CA-125 levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Consult your doctor for more details.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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